Drd3-flox Mouse
Common Name
Drd3-flox
제품 ID
S-CKO-02092
Backgroud
C57BL/6JCya
품종 계통계통 ID
CKOCMP-13490-Drd3-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Drd3-flox Mouse (카탈로그 번호 S-CKO-02092)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Drd3-flox
품종 계통계통 ID
CKOCMP-13490-Drd3-B6J-VA
유전자명
제품 ID
S-CKO-02092
유전자 별칭
D3R
배경
C57BL/6JCya
NCBI ID
변형 내용
Conditional knockout
염색체
Chr 16
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000023390
NCBI 전사체 ID
NM_007877
타겟 영역
Exon 2
유효 영역 크기
~0.9 kb
유전자 연구 개요
Drd3, the dopamine receptor D3 gene, encodes a G protein-coupled receptor that is a key component of the dopamine signaling pathway. Dopamine signaling is involved in numerous physiological and neurological processes, such as motor control, reward-based learning, and emotional regulation. The gene is highly expressed in the basal ganglia, most notably the caudate nucleus [1,4].
In autism spectrum disorder (ASD), the SNP rs167771 of Drd3 has been associated with the disorder in samples from multiple regions. The polymorphisms of rs167771 are significantly linked to a specific repetitive and stereotyped behavior called sameness. Additionally, these polymorphisms are related to risperidone-induced extra-pyramidal side effects in ASD patients. Moreover, an association between alleles of the rs167771 SNP and the volume of striatal structures was found, with greater caudate nucleus volume correlating with stereotyped behavior [1,4].
In schizophrenia, the Ser9Gly polymorphism of Drd3 is associated with treatment response to antipsychotic drugs in Caucasians but not in Asians. The Ser allele and Ser/Ser genotype contribute to poor treatment response in Caucasians [2].
Early life stress (ELS)-induced downregulation of Drd3 signaling in the lateral septum causes social abnormalities in adulthood, and optogenetic or pharmacological activation of Drd3-expressing neurons in the lateral septum rescues these impairments [3].
In Parkinson's disease, the Drd3 Ser9Gly polymorphism might be associated with the severity of depression characterized by anhedonia [5].
In ADHD, the T allele of the Ser-9-Gly polymorphism in Drd3 shows a nominal association with increased risk for ADHD, response to placebo and methylphenidate, and modulation of other behavioral and cognitive dimensions. Also, COMT and Drd3 genetic variants may interact to play a role in ADHD symptomatology and response to treatment [6,7].
In conclusion, Drd3 plays a crucial role in various neurological and psychiatric conditions, including autism, schizophrenia, Parkinson's disease, and ADHD. Through genetic studies and animal models, we have gained insights into how Drd3 polymorphisms and signaling alterations contribute to the pathophysiology of these diseases, which may potentially lead to the development of more targeted therapeutic strategies.
References：
1. Staal, Wouter G. 2014. Autism, DRD3 and repetitive and stereotyped behavior, an overview of the current knowledge. In European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 25, 1421-6. doi:10.1016/j.euroneuro.2014.08.011. https://pubmed.ncbi.nlm.nih.gov/25224105/
2. Liu, Chuanyong, Xu, Xiaohong, Liu, Xiaoyan, Li, Yaoyao, Yan, Pan. 2022. DRD3 Ser9Gly polymorphism and treatment response to antipsychotics in schizophrenia: A meta-analysis. In Neuroscience letters, 786, 136788. doi:10.1016/j.neulet.2022.136788. https://pubmed.ncbi.nlm.nih.gov/35835396/
3. Shin, Sora, Pribiag, Horia, Lilascharoen, Varoth, Wang, Xiao-Yun, Lim, Byung Kook. 2017. Drd3 Signaling in the Lateral Septum Mediates Early Life Stress-Induced Social Dysfunction. In Neuron, 97, 195-208.e6. doi:10.1016/j.neuron.2017.11.040. https://pubmed.ncbi.nlm.nih.gov/29276054/
4. Staal, Wouter G, Langen, Marieke, van Dijk, Sarai, Mensen, Vincent T, Durston, Sarah. 2015. DRD3 gene and striatum in autism spectrum disorder. In The British journal of psychiatry : the journal of mental science, 206, 431-2. doi:10.1192/bjp.bp.114.148973. https://pubmed.ncbi.nlm.nih.gov/25792691/
5. Zhi, Yan, Yuan, Yongsheng, Si, Qianqian, Zhang, Hui, Zhang, Kezhong. 2019. The Association between DRD3 Ser9Gly Polymorphism and Depression Severity in Parkinson's Disease. In Parkinson's disease, 2019, 1642087. doi:10.1155/2019/1642087. https://pubmed.ncbi.nlm.nih.gov/31143436/
6. Fageera, Weam, Sengupta, Sarojini M, Labbe, Aurelie, Grizenko, Natalie, Joober, Ridha. 2018. DRD3 Gene and ADHD: A Pharmaco-Behavioural Genetic Study. In Neuromolecular medicine, 20, 515-524. doi:10.1007/s12017-018-8504-z. https://pubmed.ncbi.nlm.nih.gov/30051166/
7. Fageera, Weam, Grizenko, Natalie, Sengupta, Sarojini M, Schmitz, Norbert, Joober, Ridha. 2020. COMT by DRD3 Epistatic Interaction in Modulating Behaviors in Children with ADHD: A Pharmaco-Dynamic Behavioral Approach. In Journal of attention disorders, 25, 1720-1730. doi:10.1177/1087054720934191. https://pubmed.ncbi.nlm.nih.gov/32564645/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
Cyagen문의하기
맞춤형 동물 모델 관련 상담을 위해 Cyagen 전문가와 연락해 보세요. 아래 양식을 작성하여 상담을 시작하거나 견적을 요청하시기 바랍니다.
Cyagen은 고객님의 개인정보를 소중히 여깁니다. 최신 제품, 서비스 및 인사이트를 안내드리고자 합니다. 고객님의 수신 설정은 다음과 같습니다:
해당 커뮤니케이션은 언제든지 수신 거부하실 수 있습니다. 수신 거부 방법 및 데이터 보호에 대한 자세한 내용은 개인정보처리방침을 참고해 주시기 바랍니다.
아래 버튼을 클릭함으로써, 요청하신 콘텐츠 제공을 위해 본 양식을 통해 제출된 개인정보를 Cyagen이 저장 및 처리하는 데 동의하게 됩니다.