Mrps15-flox Mouse
Common Name
Mrps15-flox
제품 ID
S-CKO-13066
Backgroud
C57BL/6JCya
품종 계통계통 ID
CKOCMP-66407-Mrps15-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Mrps15-flox Mouse (카탈로그 번호 S-CKO-13066)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Mrps15-flox
품종 계통계통 ID
CKOCMP-66407-Mrps15-B6J-VA
유전자명
제품 ID
S-CKO-13066
유전자 별칭
Mprs15, 1500003E24Rik, 2410002B11Rik
배경
C57BL/6JCya
NCBI ID
변형 내용
Conditional knockout
염색체
Chr 4
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000030675
NCBI 전사체 ID
NM_025544
타겟 영역
Exon 3~4
유효 영역 크기
~2.8 kb
유전자 연구 개요
Mrps15, a mitochondrial ribosomal protein gene, is an essential component for the structural and functional integrity of the mitoribosome complex. Mammalian mitoribosomes have acquired new Mrp genes during evolution, and Mrps15 is among them. Mitoribosomes are crucial for mitochondrial translation of protein components of the OXPHOS complex, thus Mrps15 is likely involved in maintaining mitochondrial function and energy metabolism [1,5].
In stressed cardiomyocytes, MRPS15 translocates to cytosolic ribosomes and regulates internal ribosome entry site (IRES)-dependent translation, playing a role in controlling gene expression under stress conditions [2].
In hepatocellular carcinoma, a prognostic model integrating MRPS15 and other genes shows better clinical net benefit, indicating its potential in predicting prognosis [3].
In lung adenocarcinoma, MRPS15 is among hub genes influenced by smoke-induced differential DNA methylation, enriching in RNA processing, ribosome biogenesis, and mitochondrial translation, crucial for cancer progression [4].
In collagen VI-related dystrophies, MRPS15 is identified as a potential hub gene, providing insights into disease-related pathophysiological pathways [6].
In summary, Mrps15 is vital for mitoribosome function and is involved in various biological processes and disease conditions. Its role in stress-related translation regulation, cancer prognosis, and rare muscle disorders highlights its significance in understanding disease mechanisms, offering potential targets for therapeutic interventions.
References：
1. Cheong, Agnes, Lingutla, Ranjana, Mager, Jesse. 2020. Expression analysis of mammalian mitochondrial ribosomal protein genes. In Gene expression patterns : GEP, 38, 119147. doi:10.1016/j.gep.2020.119147. https://pubmed.ncbi.nlm.nih.gov/32987154/
2. David, Florian, Roussel, Emilie, Froment, Carine, Garmy-Susini, Barbara, Prats, Anne-Catherine. 2024. Mitochondrial Ribosomal Protein MRPS15 Is a Component of Cytosolic Ribosomes and Regulates Translation in Stressed Cardiomyocytes. In International journal of molecular sciences, 25, . doi:10.3390/ijms25063250. https://pubmed.ncbi.nlm.nih.gov/38542224/
3. Zhao, Jin-Wei, Zhao, Wei-Yi, Cui, Xin-Hua, Shi, Jia-Cheng, Yu, Lu. 2023. The role of the mitochondrial ribosomal protein family in detecting hepatocellular carcinoma and predicting prognosis, immune features, and drug sensitivity. In Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 26, 496-514. doi:10.1007/s12094-023-03269-4. https://pubmed.ncbi.nlm.nih.gov/37407805/
4. Mukherjee, Arnab, Boonbangyang, Manon, K S, Mukunthan. 2025. Unraveling the intricate molecular landscape and potential biomarkers in lung adenocarcinoma through integrative epigenomic and transcriptomic profiling. In Scientific reports, 15, 9154. doi:10.1038/s41598-025-93769-w. https://pubmed.ncbi.nlm.nih.gov/40097569/
5. Sotgia, Federica, Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E, Howell, Anthony, Lisanti, Michael P. 2012. Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. In Cell cycle (Georgetown, Tex.), 11, 4390-401. doi:10.4161/cc.22777. https://pubmed.ncbi.nlm.nih.gov/23172368/
6. Ceyhan, Atakan Burak, Kaynar, Ali, Altay, Ozlem, Turkez, Hasan, Mardinoglu, Adil. 2024. Identifying Hub Genes and Metabolic Pathways in Collagen VI-Related Dystrophies: A Roadmap to Therapeutic Intervention. In Biomolecules, 14, . doi:10.3390/biom14111376. https://pubmed.ncbi.nlm.nih.gov/39595553/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
Cyagen문의하기
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