Eif4enif1-flox Mouse

Eif4enif1, also known as eukaryotic translation initiation factor 4E nuclear import factor 1, encodes an eukaryotic translation initiation factor 4E transporter (4E-T) protein. It suppresses the expression of capped mRNAs, playing a role in inhibiting mRNA translation and regulating mRNA destabilization [6].

Eif4enif1 haploinsufficiency in mouse models causes subfertility, impairs oocyte maturation and partially arrests early embryonic development. Dual-omic sequencing shows it significantly alters both transcriptome and translatome in mouse oocytes, leading to oocyte mitochondrial hyperfusion and mitochondria-associated ribonucleoprotein domain distribution alteration [1]. In human studies, various Eif4enif1 variants have been identified in patients with non-syndromic premature ovarian insufficiency (POI). These variants exhibit reduced mRNA and protein expression levels, and impaired translation regulation abilities, potentially contributing to POI [2,3,4,5].

In conclusion, Eif4enif1 is crucial for normal oocyte development and ovarian function. Mouse models with Eif4enif1 haploinsufficiency have provided insights into the molecular mechanisms underlying infertility, especially those related to POI. Understanding Eif4enif1's function may offer new therapeutic targets for infertility treatment.