Sat1-KO Mouse
Common Name
Sat1-KO
제품 ID
S-KO-04195
Backgroud
C57BL/6NCya
품종 계통계통 ID
KOCMP-20229-Sat1-B6N-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Sat1-KO Mouse (카탈로그 번호 S-KO-04195)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Sat1-KO
품종 계통계통 ID
KOCMP-20229-Sat1-B6N-VA
유전자명
제품 ID
S-KO-04195
유전자 별칭
Sat, SSAT
배경
C57BL/6NCya
NCBI ID
변형 내용
Conventional knockout
염색체
Chr X
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000026318
NCBI 전사체 ID
NM_009121
타겟 영역
Exon 1~6
유효 영역 크기
~3.3 kb
유전자 연구 개요
Sat1, also known as spermidine/spermine N1-acetyltransferase 1, is a rate-limiting enzyme in polyamine catabolism. It is critically involved in converting spermidine and spermine back to putrescine. The gene participates in polyamine metabolism and is associated with pathways like ferroptosis, which is a form of regulated cell death. Understanding Sat1 is crucial as it impacts various biological processes and disease conditions [1,2,3,4,7,9].
In several disease models, the role of Sat1 has been revealed. In triple-negative breast cancer, high SAT1 expression is associated with poor prognoses, and SAT1 knockdown inhibits cell proliferation and migration, suggesting it drives tumor progression through the SAT1/YBX1/mTOR axis [5]. In an osteoporosis murine model, osteoclasts express a high level of SAT1 during osteoclastogenesis, and targeting SAT1 with Berenil promotes osteoclast apoptosis, reversing bone loss [6]. In X-linked childhood-onset systemic lupus erythematosus, loss-of-function variants in SAT1 were identified in affected families, and Sat1 p.Glu92Leufs*6 KI mice spontaneously developed lupus-like symptoms, highlighting the pathogenic role of dysregulated polyamine catabolism [8].
In conclusion, Sat1 plays essential roles in polyamine metabolism and is implicated in multiple disease conditions such as cancer, osteoporosis, and lupus. Gene-knockout and knock-in mouse models have been instrumental in uncovering its functions in these diseases, providing potential therapeutic targets for treatment.
References:
1. Ou, Yang, Wang, Shang-Jui, Li, Dawei, Chu, Bo, Gu, Wei. 2016. Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses. In Proceedings of the National Academy of Sciences of the United States of America, 113, E6806-E6812. doi:. https://pubmed.ncbi.nlm.nih.gov/27698118/
2. Murthy, Divya, Attri, Kuldeep S, Shukla, Surendra K, Wellen, Kathryn E, Singh, Pankaj K. 2024. Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis. In Nature cell biology, 26, 613-627. doi:10.1038/s41556-024-01372-4. https://pubmed.ncbi.nlm.nih.gov/38429478/
3. Wan, Kexing, Jia, Min, Zhang, Hong, Liu, Yongmin, Li, Man. 2023. Electroacupuncture Alleviates Neuropathic Pain by Suppressing Ferroptosis in Dorsal Root Ganglion via SAT1/ALOX15 Signaling. In Molecular neurobiology, 60, 6121-6132. doi:10.1007/s12035-023-03463-z. https://pubmed.ncbi.nlm.nih.gov/37421564/
4. Dang, Yini, He, Qing, Yang, Siyu, Zheng, Yu, Wu, Ting. 2022. FTH1- and SAT1-Induced Astrocytic Ferroptosis Is Involved in Alzheimer's Disease: Evidence from Single-Cell Transcriptomic Analysis. In Pharmaceuticals (Basel, Switzerland), 15, . doi:10.3390/ph15101177. https://pubmed.ncbi.nlm.nih.gov/36297287/
5. Tian, Wenwen, Zhu, Lewei, Luo, Yongzhou, Xie, Xiaoming, Ye, Feng. 2024. Autophagy Deficiency Induced by SAT1 Potentiates Tumor Progression in Triple-Negative Breast Cancer. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11, e2309903. doi:10.1002/advs.202309903. https://pubmed.ncbi.nlm.nih.gov/39073262/
6. Jin, Zhichun, Xu, Hao, Sun, Xueyu, Yan, Bin, Wang, Lin. 2024. Targeting SAT1 prevents osteoporosis through promoting osteoclast apoptosis. In Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 175, 116732. doi:10.1016/j.biopha.2024.116732. https://pubmed.ncbi.nlm.nih.gov/38739990/
7. Yang, Huihuang, Li, Yingmin, Zhu, Weihao, Cong, Bin, Shi, Weibo. 2024. SAT1/ALOX15 Signaling Pathway Is Involved in Ferroptosis After Skeletal Muscle Contusion. In International journal of molecular sciences, 25, . doi:10.3390/ijms252011317. https://pubmed.ncbi.nlm.nih.gov/39457099/
8. Xu, Lingxiao, Zhao, Jian, Sun, Qing, Gilkeson, Gary S, Tsao, Betty P. 2022. Loss-of-function variants in SAT1 cause X-linked childhood-onset systemic lupus erythematosus. In Annals of the rheumatic diseases, 81, 1712-1721. doi:10.1136/ard-2022-222795. https://pubmed.ncbi.nlm.nih.gov/35977808/
9. Xu, Jingting, Ruan, Zhaoxuan, Guo, Zhou, Sun, Kai, Guo, Fengjing. 2024. Inhibition of SAT1 alleviates chondrocyte inflammation and ferroptosis by repressing ALOX15 expression and activating the Nrf2 pathway. In Bone & joint research, 13, 110-123. doi:10.1302/2046-3758.133.BJR-2023-0250.R1. https://pubmed.ncbi.nlm.nih.gov/38447596/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
Cyagen문의하기
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