Tex26-KO Mouse

Tex26, while its exact essential function, associated pathways, and overall biological importance are yet to be fully defined, has been implicated in various biological processes. Its study through genetic models like gene knockout (KO) or conditional knockout (CKO) mouse models could potentially shed more light on its functions.

In a study on sex-specific genetic and transcriptomic liability to neuroticism, genetically regulated transcriptomic changes highlighted the effect of Tex26, suggesting its role in molecular pathways related to neurotic symptoms and their psychiatric comorbidities [1]. In glioma research, a gene signature model including Tex26 was constructed, and it showed good performance in predicting survival time for glioma patients, with higher scores correlated with malignant features [2]. In bicuspid aortic valve (BAV) studies, a TEX26 genetic variant was associated with BAV in men, indicating a possible role of gender-specific polymorphisms in BAV development [3]. In breast cancer research, an lncRNA TEX26-AS1 was found to be co-expressed with ADORA2B, hinting at potential involvement in breast cancer progression [4]. In amyotrophic lateral sclerosis (ALS) models, Tex26 mRNA was identified as deregulated in motor neurons at motor symptom onset in TDP-43-driven ALS models [5]. In a study on blood lipids in Indians, TEX26 was associated with triglyceride levels [6]. In human blastocysts, TEX26 was among the genes differentially expressed between non-implanted and live-birth-resulting blastocysts [7]. In a rat epigenome study, there was evidence for sex-specific DNA methylation and expression differences at Tex26, which is involved in neurodevelopment [8].

In summary, Tex26 seems to be involved in multiple biological processes and disease conditions. Studies in various disease areas such as neuroticism, glioma, BAV, breast cancer, ALS, lipid regulation, embryo implantation, and neurodevelopment suggest its potential importance in these biological and pathological contexts. However, more research using KO or CKO mouse models is needed to precisely define its functions and understand its mechanisms of action in these processes.

References:

1. Wendt, Frank R, Pathak, Gita A, Singh, Kritika, Davis, Lea K, Polimanti, Renato. 2022. Sex-Specific Genetic and Transcriptomic Liability to Neuroticism. In Biological psychiatry, 93, 243-252. doi:10.1016/j.biopsych.2022.07.019. https://pubmed.ncbi.nlm.nih.gov/36244801/

2. Chen, Luoyi, Zhao, Xinchen, Liu, Yuyang, Xu, Chuan, Shi, Ying. 2022. Comprehensive analysis of HHV-6 and HHV-7-related gene signature in prognosis and response to temozolomide of glioma. In Journal of medical virology, 95, e28285. doi:10.1002/jmv.28285. https://pubmed.ncbi.nlm.nih.gov/36349462/

3. Dargis, Natasha, Lamontagne, Maxime, Gaudreault, Nathalie, Mathieu, Patrick, Bossé, Yohan. 2015. Identification of Gender-Specific Genetic Variants in Patients With Bicuspid Aortic Valve. In The American journal of cardiology, 117, 420-6. doi:10.1016/j.amjcard.2015.10.058. https://pubmed.ncbi.nlm.nih.gov/26708639/

4. Dong, Ying, Zhang, Ting, Li, Xining, Yu, Feng, Guo, Yue. 2018. Comprehensive analysis of coexpressed long noncoding RNAs and genes in breast cancer. In The journal of obstetrics and gynaecology research, 45, 428-437. doi:10.1111/jog.13840. https://pubmed.ncbi.nlm.nih.gov/30362198/

5. Marques, Rita F, Engler, Jan B, Küchler, Katrin, Friese, Manuel A, Duncan, Kent E. . Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models. In Human molecular genetics, 29, 2647-2661. doi:10.1093/hmg/ddaa140. https://pubmed.ncbi.nlm.nih.gov/32686835/

6. Bandesh, Khushdeep, Prasad, Gauri, Giri, Anil K, Tandon, Nikhil, Bharadwaj, Dwaipayan. 2019. Genome-wide association study of blood lipids in Indians confirms universality of established variants. In Journal of human genetics, 64, 573-587. doi:10.1038/s10038-019-0591-7. https://pubmed.ncbi.nlm.nih.gov/30911093/

7. Kirkegaard, Kirstine, Villesen, Palle, Jensen, Jacob Malte, Ingerslev, Hans Jakob, Lykke-Hartmann, Karin. 2015. Distinct differences in global gene expression profiles in non-implanted blastocysts and blastocysts resulting in live birth. In Gene, 571, 212-20. doi:10.1016/j.gene.2015.06.057. https://pubmed.ncbi.nlm.nih.gov/26117173/

8. Cox, Olivia H, Seifuddin, Fayaz, Guo, Jeffrey, Tamashiro, Kellie L K, Lee, Richard S. 2024. Implementation of the Methyl-Seq platform to identify tissue- and sex-specific DNA methylation differences in the rat epigenome. In Epigenetics, 19, 2393945. doi:10.1080/15592294.2024.2393945. https://pubmed.ncbi.nlm.nih.gov/39306700/