필터
“17533” 에 대한 검색 결과 5 건
정렬 기준:
알파벳순 (A-Z)
베스트셀러
Mrc1-iCre-tdTomato
제품 ID:
C001999
계통(Strain):
C57BL/6JCya
상태:
설명:
The Mrc1 gene (Mannose Receptor C-Type 1) encodes the CD206 protein, a prominent type I transmembrane glycoprotein characterized by multiple carbohydrate-recognition domains. Primarily expressed by macrophages and dendritic cells, particularly those exhibiting an M2-polarized (pro-inflammatory resolution) phenotype, the gene is also active in hepatic sinusoidal endothelial cells and certain barrier tissues [1]. The encoded protein functions as a pattern recognition receptor that facilitates the endocytosis of glycoproteins and various pathogens by binding to terminal mannose, fucose, or N-acetylglucosamine residues [2]. Beyond its role in innate immunity and pathogen clearance, Mrc1 is a critical marker for identifying perivascular macrophages and interstitial macrophages within the connective tissues of various organs, including the lungs, liver, and dermis [3].
Mrc1‑iCre‑tdTomato mice were generated by replacing the TAG stop codon of the mouse Mrc1 gene with the P2A‑iCre‑T2A‑tdTomato expression cassette. When Mrc1‑iCre‑tdTomato mice are crossed with mice containing loxP sites, Cre‑mediated recombination between loxP sites is expected to occur in Mrc1‑positive cells of the offspring.
The Mrc1 gene (Mannose Receptor C-Type 1) encodes the CD206 protein, a prominent type I transmembrane glycoprotein characterized by multiple carbohydrate-recognition domains. Primarily expressed by macrophages and dendritic cells, particularly those exhibiting an M2-polarized (pro-inflammatory resolution) phenotype, the gene is also active in hepatic sinusoidal endothelial cells and certain barrier tissues [1]. The encoded protein functions as a pattern recognition receptor that facilitates the endocytosis of glycoproteins and various pathogens by binding to terminal mannose, fucose, or N-acetylglucosamine residues [2]. Beyond its role in innate immunity and pathogen clearance, Mrc1 is a critical marker for identifying perivascular macrophages and interstitial macrophages within the connective tissues of various organs, including the lungs, liver, and dermis [3].
Mrc1‑iCre‑tdTomato mice were generated by replacing the TAG stop codon of the mouse Mrc1 gene with the P2A‑iCre‑T2A‑tdTomato expression cassette. When Mrc1‑iCre‑tdTomato mice are crossed with mice containing loxP sites, Cre‑mediated recombination between loxP sites is expected to occur in Mrc1‑positive cells of the offspring.
Mrc1-KO
제품 ID:
S-KO-23674
계통(Strain):
C57BL/6JCya
상태:
설명:
Mrc1 is located on chromosome 2 of mice. Nuclease Technology was used to design sgRNA; Mrc1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Mrc1 is located on chromosome 2 of mice. Nuclease Technology was used to design sgRNA; Mrc1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Pcf11-flox
제품 ID:
S-CKO-17533
계통(Strain):
C57BL/6JCya
상태:
설명:
Pcf11 is located on chromosome 7 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Pcf11 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Pcf11 is located on chromosome 7 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Pcf11 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Srsf4-KO
제품 ID:
S-KO-17533
계통(Strain):
C57BL/6JCya
상태:
설명:
Srsf4 is located on chromosome 4 of mice. Nuclease Technology was used to design sgRNA; Srsf4 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Srsf4 is located on chromosome 4 of mice. Nuclease Technology was used to design sgRNA; Srsf4 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Mrc1-flox
제품 ID:
S-CKO-03785
계통(Strain):
C57BL/6JCya
상태:
설명:
Mrc1 is located on chromosome 2 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Mrc1 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Mrc1 is located on chromosome 2 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Mrc1 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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