필터
“20289” 에 대한 검색 결과 5 건
정렬 기준:
알파벳순 (A-Z)
베스트셀러
Scx-P2A-iCre
제품 ID:
C002050
계통(Strain):
C57BL/6JCya
상태:
설명:
Scx (Scleraxis) is a basic helix-loop-helix (bHLH) transcription factor that plays critical regulatory roles during the development of tendons, ligaments, heart valves, and certain mesenchymal tissues [1-3]. Scx is primarily expressed in tenocytes, ligament cells, and mesenchymal progenitor cells, where it regulates the expression of extracellular matrix-related genes such as Col1a1 and participates in biological processes including tendon formation, tissue remodeling, and injury repair [2-4]. Studies have shown that Scx functionally interacts with multiple development- and fibrosis-associated factors, including Smad3, Mkx, Sox9, Runx2, and the Tgfb family, and plays important roles in heart valve development, myocardial fibrosis, and musculoskeletal injury repair [3-5]. Previous studies have also demonstrated that aberrant Scx expression may lead to mesoderm developmental abnormalities, impaired tendon formation, and skeletal-related defects [5].
Scx-P2A-iCre mice were generated by replacing the endogenous Scx stop codon with a P2A-iCre cassette, enabling the expression of codon-optimized iCre recombinase under the control of endogenous Scx regulatory elements. When crossed with mice containing loxP sites, Cre-mediated recombination between loxP sites is expected to occur in Scx-positive cells of the offspring.
Scx (Scleraxis) is a basic helix-loop-helix (bHLH) transcription factor that plays critical regulatory roles during the development of tendons, ligaments, heart valves, and certain mesenchymal tissues [1-3]. Scx is primarily expressed in tenocytes, ligament cells, and mesenchymal progenitor cells, where it regulates the expression of extracellular matrix-related genes such as Col1a1 and participates in biological processes including tendon formation, tissue remodeling, and injury repair [2-4]. Studies have shown that Scx functionally interacts with multiple development- and fibrosis-associated factors, including Smad3, Mkx, Sox9, Runx2, and the Tgfb family, and plays important roles in heart valve development, myocardial fibrosis, and musculoskeletal injury repair [3-5]. Previous studies have also demonstrated that aberrant Scx expression may lead to mesoderm developmental abnormalities, impaired tendon formation, and skeletal-related defects [5].
Scx-P2A-iCre mice were generated by replacing the endogenous Scx stop codon with a P2A-iCre cassette, enabling the expression of codon-optimized iCre recombinase under the control of endogenous Scx regulatory elements. When crossed with mice containing loxP sites, Cre-mediated recombination between loxP sites is expected to occur in Scx-positive cells of the offspring.
Zcwpw1-KO
제품 ID:
S-KO-20289
계통(Strain):
C57BL/6JCya
상태:
설명:
Zcwpw1 is located on chromosome 5 of mice. Nuclease Technology was used to design sgRNA; Zcwpw1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Zcwpw1 is located on chromosome 5 of mice. Nuclease Technology was used to design sgRNA; Zcwpw1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Scx-KO
제품 ID:
S-KO-24584
계통(Strain):
C57BL/6JCya
상태:
설명:
Scx is located on chromosome 15 of mice. Nuclease Technology was used to design sgRNA; Scx knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Scx is located on chromosome 15 of mice. Nuclease Technology was used to design sgRNA; Scx knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Scx-KO
제품 ID:
S-KO-04220
계통(Strain):
C57BL/6JCya
상태:
설명:
Scx is located on chromosome 15 of mice. Nuclease Technology was used to design sgRNA; Scx knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Scx is located on chromosome 15 of mice. Nuclease Technology was used to design sgRNA; Scx knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Scx-flox
제품 ID:
S-CKO-19831
계통(Strain):
C57BL/6JCya
상태:
설명:
Scx is located on chromosome 15 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Scx conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Scx is located on chromosome 15 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Scx conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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