필터
“695” 에 대한 검색 결과 7 건
정렬 기준:
알파벳순 (A-Z)
베스트셀러
B6-hBTK
제품 ID:
C001868
계통(Strain):
C57BL/6NCya
상태:
설명:
The Bruton's Tyrosine Kinase (BTK) is a non-receptor cytoplasmic tyrosine kinase encoded by the BTK gene, which is primarily expressed in hematopoietic tissues including B cells, mast cells, macrophages, and platelets, and produces multiple protein isoforms via alternative splicing. Its crucial function is to serve as a key component of the B-cell receptor (BCR) signaling pathway, promoting essential B-cell development, proliferation, differentiation, and survival, as well as playing roles in innate immunity signaling via Toll-like receptors (TLRs) and Fc receptors, and in osteoclast and platelet function [1]. Mutations in the BTK gene cause the primary immunodeficiency X-linked agammaglobulinemia (XLA), characterized by the failure to produce mature B lymphocytes, while its overactivation and overexpression are implicated in a range of associated diseases, most notably B-cell malignancies such as Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL), as well as autoimmune conditions like Sjogren's syndrome and Multiple Sclerosis (MS), making BTK a major therapeutic target for small-molecule inhibitors [2]. BTK inhibitors may also find a role in severe allergic disease, such as food allergy [3].
B6-hBTK mouse is a humanized model generated using gene editing technology, in which the coding sequence of exon 2 to partial intron 4 was replaced with Kozak-Human BTK CDS-3’UTR of Mouse Btk-WPRE-BGH pA cassette. This model can be used to study the pathological mechanisms and therapeutic approaches of B-cell malignancies, autoimmune conditions, and severe allergic disease, as well as for the development of BTK-targeted drugs.
The Bruton's Tyrosine Kinase (BTK) is a non-receptor cytoplasmic tyrosine kinase encoded by the BTK gene, which is primarily expressed in hematopoietic tissues including B cells, mast cells, macrophages, and platelets, and produces multiple protein isoforms via alternative splicing. Its crucial function is to serve as a key component of the B-cell receptor (BCR) signaling pathway, promoting essential B-cell development, proliferation, differentiation, and survival, as well as playing roles in innate immunity signaling via Toll-like receptors (TLRs) and Fc receptors, and in osteoclast and platelet function [1]. Mutations in the BTK gene cause the primary immunodeficiency X-linked agammaglobulinemia (XLA), characterized by the failure to produce mature B lymphocytes, while its overactivation and overexpression are implicated in a range of associated diseases, most notably B-cell malignancies such as Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL), as well as autoimmune conditions like Sjogren's syndrome and Multiple Sclerosis (MS), making BTK a major therapeutic target for small-molecule inhibitors [2]. BTK inhibitors may also find a role in severe allergic disease, such as food allergy [3].
B6-hBTK mouse is a humanized model generated using gene editing technology, in which the coding sequence of exon 2 to partial intron 4 was replaced with Kozak-Human BTK CDS-3’UTR of Mouse Btk-WPRE-BGH pA cassette. This model can be used to study the pathological mechanisms and therapeutic approaches of B-cell malignancies, autoimmune conditions, and severe allergic disease, as well as for the development of BTK-targeted drugs.
NKG-SGM3/hIL6/Kit*V831M
제품 ID:
C001695
계통(Strain):
NKG
상태:
설명:
NKG mice are a type of severe immunodeficient mouse developed by Cyagen by deleting the Il2rg gene from the NOD-Scid strain. This strain lacks mature T, B, and NK cells, has reduced complement activity, and weak macrophage phagocytosis of human cells. As a result, NKG mice can efficiently engraft human hematopoietic stem cells (HSC), peripheral blood mononuclear cells (PBMC), patient-derived xenografts (PDX), or adult stem cells and tissues.
Interleukin-6 (IL-6) is a cytokine that plays a crucial role in inflammation and B cell maturation. It is primarily produced and secreted into the bloodstream at acute and chronic inflammatory sites. IL-6 induces transcriptional inflammatory responses through its receptor, IL6Rα. Research indicates that immunodeficient mice carrying the human IL6 gene effectively enhance the differentiation of human monocytes and macrophages during HSC reconstruction [1].
The KIT gene encodes a receptor tyrosine kinase (c-Kit or CD117) that is activated by its ligand, stem cell factor (SCF). Activation of this receptor triggers phosphorylation of a variety of downstream intracellular proteins, governing essential cellular processes such as proliferation, differentiation, migration, and apoptosis across numerous cell types. The KIT gene plays a pivotal role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and the development and function of mast cells. Mutations in KIT are implicated in a range of pathologies, including gastrointestinal stromal tumors, mastocytosis, and acute myeloid leukemia. Importantly, immunodeficient mice harboring the KIT W41 mutation (V831M) have demonstrated the ability to undergo human HSC transplantation without the need for irradiation, while maintaining high rates of engraftment [2-3].
The SCF gene, also known as KITLG, encodes the receptor-type protein-tyrosine kinase KIT ligand. This gene is crucial for the development of germ cells and neurons during embryogenesis and plays a significant role in hematopoiesis. The GM-CSF gene, or CSF2, encodes a cytokine that orchestrates the production, differentiation, and function of granulocytes and macrophages. Meanwhile, the IL3 gene encodes a growth-promoting cytokine essential for the proliferation of various blood cell types, influencing cell growth, differentiation, and apoptosis. Research demonstrates that severe immunodeficient mice expressing human IL3, GM-CSF (CSF2), and SCF (KITLG) show markedly enhanced engraftment efficiency in the xenotransplantation of acute myeloid leukemia (AML) [4], supporting stable engraftment of myeloid lineages and regulatory T cell populations [5].
NKG-SGM3/hIL6/Kit*V831M mice are mouse models obtained by mating KIT W41 mutation (V831M) mouse models (Catalog Number: I001175) with IL6 humanized mouse models (Catalog Number: I001176) and IL3, KITLG and CSF2 triple humanized mouse models (Catalog Number: I001177). These mice express human IL6, IL3, KITLG, and CSF2 genomic sequences, as well as mouse KIT genomic sequences carrying the W41 mutation (V831M). This model is a valuable tool for immuno-oncology, immunology, and infectious disease research.
NKG mice are a type of severe immunodeficient mouse developed by Cyagen by deleting the Il2rg gene from the NOD-Scid strain. This strain lacks mature T, B, and NK cells, has reduced complement activity, and weak macrophage phagocytosis of human cells. As a result, NKG mice can efficiently engraft human hematopoietic stem cells (HSC), peripheral blood mononuclear cells (PBMC), patient-derived xenografts (PDX), or adult stem cells and tissues.
Interleukin-6 (IL-6) is a cytokine that plays a crucial role in inflammation and B cell maturation. It is primarily produced and secreted into the bloodstream at acute and chronic inflammatory sites. IL-6 induces transcriptional inflammatory responses through its receptor, IL6Rα. Research indicates that immunodeficient mice carrying the human IL6 gene effectively enhance the differentiation of human monocytes and macrophages during HSC reconstruction [1].
The KIT gene encodes a receptor tyrosine kinase (c-Kit or CD117) that is activated by its ligand, stem cell factor (SCF). Activation of this receptor triggers phosphorylation of a variety of downstream intracellular proteins, governing essential cellular processes such as proliferation, differentiation, migration, and apoptosis across numerous cell types. The KIT gene plays a pivotal role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and the development and function of mast cells. Mutations in KIT are implicated in a range of pathologies, including gastrointestinal stromal tumors, mastocytosis, and acute myeloid leukemia. Importantly, immunodeficient mice harboring the KIT W41 mutation (V831M) have demonstrated the ability to undergo human HSC transplantation without the need for irradiation, while maintaining high rates of engraftment [2-3].
The SCF gene, also known as KITLG, encodes the receptor-type protein-tyrosine kinase KIT ligand. This gene is crucial for the development of germ cells and neurons during embryogenesis and plays a significant role in hematopoiesis. The GM-CSF gene, or CSF2, encodes a cytokine that orchestrates the production, differentiation, and function of granulocytes and macrophages. Meanwhile, the IL3 gene encodes a growth-promoting cytokine essential for the proliferation of various blood cell types, influencing cell growth, differentiation, and apoptosis. Research demonstrates that severe immunodeficient mice expressing human IL3, GM-CSF (CSF2), and SCF (KITLG) show markedly enhanced engraftment efficiency in the xenotransplantation of acute myeloid leukemia (AML) [4], supporting stable engraftment of myeloid lineages and regulatory T cell populations [5].
NKG-SGM3/hIL6/Kit*V831M mice are mouse models obtained by mating KIT W41 mutation (V831M) mouse models (Catalog Number: I001175) with IL6 humanized mouse models (Catalog Number: I001176) and IL3, KITLG and CSF2 triple humanized mouse models (Catalog Number: I001177). These mice express human IL6, IL3, KITLG, and CSF2 genomic sequences, as well as mouse KIT genomic sequences carrying the W41 mutation (V831M). This model is a valuable tool for immuno-oncology, immunology, and infectious disease research.
Sri-KO
제품 ID:
S-KO-00695
계통(Strain):
C57BL/6JCya
상태:
설명:
Sri is located on chromosome 5 of mice. Nuclease Technology will be used to design sgRNA; Sri knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Sri is located on chromosome 5 of mice. Nuclease Technology will be used to design sgRNA; Sri knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Lyrm2-flox
제품 ID:
S-CKO-00695
계통(Strain):
C57BL/6JCya
상태:
설명:
Lyrm2 is located on chromosome 4 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Lyrm2 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Lyrm2 is located on chromosome 4 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Lyrm2 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Gm12695-KO
제품 ID:
S-KO-23160
계통(Strain):
C57BL/6JCya
상태:
설명:
Gm12695 is located on chromosome 4 of mice. Nuclease Technology will be used to design sgRNA; Gm12695 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Gm12695 is located on chromosome 4 of mice. Nuclease Technology will be used to design sgRNA; Gm12695 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Gm12695-KO
제품 ID:
S-KO-11247
계통(Strain):
C57BL/6JCya
상태:
설명:
Gm12695 is located on chromosome 4 of mice. Nuclease Technology will be used to design sgRNA; Gm12695 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Gm12695 is located on chromosome 4 of mice. Nuclease Technology will be used to design sgRNA; Gm12695 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Gm12695-flox
제품 ID:
S-CKO-12581
계통(Strain):
C57BL/6JCya
상태:
설명:
Gm12695 is located on chromosome 4 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Gm12695 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Gm12695 is located on chromosome 4 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Gm12695 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
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