필터
“22059” 에 대한 검색 결과 9 건
정렬 기준:
알파벳순 (A-Z)
베스트셀러
Trp53-KO
제품 ID:
C001203
계통(Strain):
C57BL/6JCya
상태:
설명:
The tumor protein p53 (TP53) gene encodes P53 oncoprotein, a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The P53 oncoprotein responds to diverse cellular stresses to regulate the expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome.
This strain is a mouse model lacking Trp53, which is a gene homologous to human TP53. Homozygous Trp53-KO male mice develop normally but are prone to spontaneous tumors. Homozygous Trp53-KO mice developed tumors, mainly lymphomas, and sarcomas, at three to six months of age, and heterozygous mice developed tumors at about 10 months of age. Homozygous males are viable and fertile, but homozygous females have reduced survival at weaning.
This strain is a mouse model lacking Trp53, which is a gene homologous to human TP53. Homozygous Trp53-KO male mice develop normally but are prone to spontaneous tumors. Homozygous Trp53-KO mice developed tumors, mainly lymphomas, and sarcomas, at three to six months of age, and heterozygous mice developed tumors at about 10 months of age. Homozygous males are viable and fertile, but homozygous females have reduced survival at weaning.
The tumor protein p53 (TP53) gene encodes P53 oncoprotein, a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The P53 oncoprotein responds to diverse cellular stresses to regulate the expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome.
This strain is a mouse model lacking Trp53, which is a gene homologous to human TP53. Homozygous Trp53-KO male mice develop normally but are prone to spontaneous tumors. Homozygous Trp53-KO mice developed tumors, mainly lymphomas, and sarcomas, at three to six months of age, and heterozygous mice developed tumors at about 10 months of age. Homozygous males are viable and fertile, but homozygous females have reduced survival at weaning.
This strain is a mouse model lacking Trp53, which is a gene homologous to human TP53. Homozygous Trp53-KO male mice develop normally but are prone to spontaneous tumors. Homozygous Trp53-KO mice developed tumors, mainly lymphomas, and sarcomas, at three to six months of age, and heterozygous mice developed tumors at about 10 months of age. Homozygous males are viable and fertile, but homozygous females have reduced survival at weaning.
Trp53&Apc dKO
제품 ID:
C001909
계통(Strain):
C57BL/6JCya
상태:
설명:
The tumor protein p53 (TP53) gene encodes P53 oncoprotein, a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The P53 oncoprotein responds to diverse cellular stresses to regulate the expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism.
The adenomatous polyposis coli (APC) gene is a tumor suppressor gene, the protein it encodes plays a key regulatory role in the Wnt/β-catenin signaling pathway [1]. The APC protein can antagonize the Wnt signaling pathway, assisting in regulating cell migration, adhesion, transcriptional activation, and apoptosis. More than 10% of human tumors have mutations in the APC gene, and most colorectal cancers have mutations in the APC gene [2]. Defects in the APC gene lead to the occurrence of familial adenomatous polyposis (FAP), characterized by hundreds to thousands of adenomatous polyps in the rectum. This is an autosomal dominant precancerous disease, which usually develops into malignant tumors [1-2]. Disease-related mutations in the APC gene are highly prevalent in a small region known as the mutation cluster region (MCR), which usually leads to the production of truncated proteins [3-4]. In mice, either Apc gene deletion or multiple intestinal neoplasia (Min) mutations that result in the production of truncated APC proteins cause phenotypes similar to human familial adenomatous polyposis (FAP) and/or colorectal tumors [5-9].
Trp53 & Apc dKO mice are a double-gene knockout model obtained by mating Trp53 KO mice (catalog number: C001203) with Apc KO mice (catalog number: C001511). Homozygous knockout of the Apc gene is lethal. Trp53 & Apc dKO mice can be used for the study of the mechanisms of tumors or tumor-related diseases such as familial adenomatous polyposis (FAP) and colorectal cancer.
The tumor protein p53 (TP53) gene encodes P53 oncoprotein, a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The P53 oncoprotein responds to diverse cellular stresses to regulate the expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism.
The adenomatous polyposis coli (APC) gene is a tumor suppressor gene, the protein it encodes plays a key regulatory role in the Wnt/β-catenin signaling pathway [1]. The APC protein can antagonize the Wnt signaling pathway, assisting in regulating cell migration, adhesion, transcriptional activation, and apoptosis. More than 10% of human tumors have mutations in the APC gene, and most colorectal cancers have mutations in the APC gene [2]. Defects in the APC gene lead to the occurrence of familial adenomatous polyposis (FAP), characterized by hundreds to thousands of adenomatous polyps in the rectum. This is an autosomal dominant precancerous disease, which usually develops into malignant tumors [1-2]. Disease-related mutations in the APC gene are highly prevalent in a small region known as the mutation cluster region (MCR), which usually leads to the production of truncated proteins [3-4]. In mice, either Apc gene deletion or multiple intestinal neoplasia (Min) mutations that result in the production of truncated APC proteins cause phenotypes similar to human familial adenomatous polyposis (FAP) and/or colorectal tumors [5-9].
Trp53 & Apc dKO mice are a double-gene knockout model obtained by mating Trp53 KO mice (catalog number: C001203) with Apc KO mice (catalog number: C001511). Homozygous knockout of the Apc gene is lethal. Trp53 & Apc dKO mice can be used for the study of the mechanisms of tumors or tumor-related diseases such as familial adenomatous polyposis (FAP) and colorectal cancer.
Ier3-flox
제품 ID:
S-CKO-22059
계통(Strain):
C57BL/6JCya
상태:
설명:
Ier3 is located on chromosome 17 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Ier3 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Ier3 is located on chromosome 17 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Ier3 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Trp53-KO
제품 ID:
S-KO-16097
계통(Strain):
C57BL/6NCya
상태:
설명:
Trp53 is located on chromosome 11 of mice. Nuclease Technology was used to design sgRNA; Trp53 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Trp53 is located on chromosome 11 of mice. Nuclease Technology was used to design sgRNA; Trp53 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Trp53-KO
제품 ID:
S-KO-05567
계통(Strain):
C57BL/6JCya
상태:
설명:
Trp53 is located on chromosome 11 of mice. Nuclease Technology was used to design sgRNA; Trp53 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Trp53 is located on chromosome 11 of mice. Nuclease Technology was used to design sgRNA; Trp53 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Trp53-KO
제품 ID:
S-KO-05566
계통(Strain):
C57BL/6JCya
상태:
설명:
Trp53 is located on chromosome 11 of mice. Nuclease Technology was used to design sgRNA; Trp53 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Trp53 is located on chromosome 11 of mice. Nuclease Technology was used to design sgRNA; Trp53 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Trp53-flox
제품 ID:
S-CKO-06451
계통(Strain):
C57BL/6NCya
상태:
설명:
Trp53 is located on chromosome 11 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Trp53 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Trp53 is located on chromosome 11 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Trp53 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Trp53-flox
제품 ID:
S-CKO-06450
계통(Strain):
C57BL/6JCya
상태:
설명:
Trp53 is located on chromosome 11 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Trp53 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Trp53 is located on chromosome 11 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Trp53 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Trp53-flox
제품 ID:
S-CKO-06449
계통(Strain):
C57BL/6JCya
상태:
설명:
Trp53 is located on chromosome 11 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Trp53 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Trp53 is located on chromosome 11 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Trp53 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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