Cyagen White Paper: Applications of the Mouse Model in Translational Medical Research
Dr. Steve Yu
Senior Scientist of Cyagen
(Note: This article is translated from the original writing in Chinese)
The mouse model has become an irreplaceable model organism for biomedical research, which includes studying gene function and genetic factors of pathogenesis, establishing humanized disease models, and evaluating the safety and effectiveness of drugs under development. The rapidly growing branch of biomedical research known as translational medicine is aimed at the practical problems from clinical patients. A combination of molecular, cellular, and animal models in related basic and preclinical studies can help address the problems of translational research. Therefore, a major strategy of translational medical research is to combine the basic laboratory studies with the preclinical animal experimental research and rapidly move into clinical application.
How to Use the Appropriate Mouse Model to Publish High-Impact Articles?
“In Vivo AAV-타겟 유전자 편집-mediated Gene Editing Ameliorates Atherosclerosis in Familial Hypercholesterolemia” published in the well-known journal, Circulation, this year. Using this article, I will further explain how to apply the gene editing mouse model to carry out research about the relationship between genes and diseases and how to use gene editing to create a mouse model which will adequately evaluate the effectiveness of specific gene therapies.
Establishing a Mouse Model of Familial Hypercholesterolemia
Adeno-associated Virus (AAV)-타겟 유전자 편집 Gene Therapy
Humanized Mouse Models – Introduction and Applications
The term ‘humanized mouse’ was referred to mouse models which included the human immune system (HIS) - which was achieved by transplanting human cells or tissues into immune-deficient mice. However, the term has grown to include custom mouse models genetically engineered to express human gene products, the introduction of human intestinal microbiota into sterile mice, among other methods that may provide in vivo context for human pathologies and physiology. Thus, a humanized mouse may describe any model in which human cell tissue, genes, or intestinal microorganisms are introduced through xenotransplantation or gene editing technology.
Utility of Humanized Mouse Models
Applications in Oncology & Anti-Tumor Immunotherapy
Gut Flora & the Human Microbiome
Introduction to Immunodeficient Mouse Models & BRGSF Spotlight
The BRGSF mouse model is a valuable tool for antibody drug and vaccine development, efficacy and safety evaluation of chimeric antigen receptor (CAR) T-cell therapy, and myeloid development, as well as the best in vivo model platform to study and predict the immune response in the human body.
Improving Xenotransplantation Efficiency in Immunodeficient Mice
Characteristics and Advantages of BRGSF - A New Immunodeficient Mouse Model
At present, Cyagen can provide BRGSF immunodeficient mouse and related technical services for scientific research, pharmaceutical R&D and other related research fields. We believe that the successful construction of BRGSF immunodeficient mice will dramatically promote the application of humanized mouse models in translational medical research.
>>Learn more about Cyagen’s Mouse Models for Drug Screening and Assessment
There are numerous types of humanized mouse models to choose from. Every model comes with its own unique advantages and challenges across various research foci. Whether you are interested in genetically modified or immunodeficient models for xenotransplantation, our experts are available to provide free consultations and quotes. Contact us with your project details to receive more information within 48 hours.
About Cyagen
During 14 years of development, Cyagen has served tens of thousands of scientists around the world. Cyagen’s products and technologies have been directly applied to more than 4,300 academic papers across major journals- including Cell, Nature, and Science. In addition to providing customized services for knockout (KO), knock-in (KI) and conditional knockout (cKO) models, Cyagen also has a professional surgical disease model team, which can provide a variety of complex and sophisticated surgical disease small animal models. Cyagen’s drug screening and evaluation mouse platform can be used to search for the immunodeficient mice introduced from European and American industry leaders and the humanized mice for cardiovascular and Alzheimer's disease research. Cyagen’s international standardized sterile mouse technology platform can provide various products and services based on aseptic animal models, such as aseptic mice, aseptic animal customization services, and microbial flora transplantation services. In combination with Cyagen’s mature and stable 유전자 편집 기술 platform, you can study the specific interaction mechanisms between bacteria and genes.
