huIL1B Mouse

The IL1B gene encodes for Interleukin-1 beta (IL-1β), a potent pro-inflammatory cytokine that is a critical mediator of the inflammatory response and innate immunity. Gene expression of IL1B is primarily observed in activated macrophages and monocytes, but also in other immune cells like dendritic cells and even some epithelial cells and keratinocytes ^[1]. IL-1β is initially synthesized as an inactive precursor protein (pro-IL-1β), which then undergoes proteolytic processing by caspase-1 (CASP1/ICE) within inflammasome complexes to yield its mature, biologically active form. This mature protein plays diverse roles in cellular activities, including cell proliferation, differentiation, apoptosis, and fever generation. It is involved in inducing the production of other inflammatory mediators and activating various immune cells ^[2]. Aberrant or increased IL-1β expression and activity are associated with a wide range of inflammatory and autoinflammatory diseases, such as Cryopyrin-Associated Periodic Syndromes (CAPS), gout, rheumatoid arthritis (RA), recurrent pericarditis, and type 2 diabetes (T2D). It has also been implicated in various cancers and neurodegenerative conditions ^[3-4].

The huIL1B mouse is a humanized model, constructed by replacing the coding sequences of the endogenous mouse Il1b gene with the coding sequences of the human IL1B gene. huIL1B mice can be used for research into the pathogenesis of various inflammatory diseases, autoimmune diseases, cancers, and neurodegenerative diseases, as well as for the screening, development, and safety evaluation of IL1B-targeted drugs.