huIL15RA Mouse
제품명
huIL15RA Mouse
제품 ID
C001981
품종 계통
C57BL/6NCya-Il15ratm1(hIL15RA)/Cya
Backgroud
C57BL/6NCya
상태
이 마우스 계통을 논문에서 사용할 경우, “huIL15RA Mouse (카탈로그 번호 C001981)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
유전자명
유전자 별칭
CD215
NCBI ID
염색체
Chr 10
MGI ID
Datasheet
품종 계통 설명
The IL15RA gene, located on chromosome 10, encodes the interleukin-15 receptor subunit alpha, a high-affinity binding protein essential for mediating the biological activities of IL-15. This gene is widely expressed across various tissues, including lymphoid organs (thymus and spleen), the gastrointestinal tract, skeletal muscle, and liver, as well as by specific cell types such as monocytes, dendritic cells, and activated T and B cells. The encoded protein is unique for its "cis" and "trans-presentation" mechanisms, where it binds IL-15 within the endoplasmic reticulum and transports it to the cell surface to signal to neighboring cells expressing IL-2/IL-15 receptor β- and γ-chains. This function is critical for the proliferation and survival of Natural Killer (NK) cells and memory CD8⁺ T cells, thereby regulating innate and adaptive immune homeostasis [1]. Pathologically, dysregulation of IL15RA is associated with various autoimmune diseases like rheumatoid arthritis (RA) and psoriasis, as well as inflammatory bowel diseases (IBD) and several hematological malignancies [2].
The huIL15RA mouse is a humanized model constructed through gene-editing technology, in which the mouse Il15ra endogenous extracellular domain is replaced with the human IL15RA extracellular domain. This model can be used for research into the pathological mechanisms and related therapeutic approaches for autoimmune diseases, inflammatory diseases, and various hematologic malignancies, as well as for screening, development, and preclinical evaluation of IL15RA-targeted drugs.
Reference
Guo Y, Luan L, Patil NK, Sherwood ER. Immunobiology of the IL-15/IL-15Rα complex as an antitumor and antiviral agent. Cytokine Growth Factor Rev. 2017 Dec;38:10-21.
Meghnem D, Maillasson M, Barbieux I, Morisseau S, Keita D, Jacques Y, Quéméner A, Mortier E. Selective Targeting of IL-15Rα Is Sufficient to Reduce Inflammation. Front Immunol. 2022 May 3;13:886213.
변형 전략
The mouse Il15ra endogenous extracellular domain was replaced with the human IL15RA extracellular domain.
Figure 1. Gene editing strategy of huIL15RA mice.
응용 분야
Screening, development, and preclinical evaluation of IL15RA-targeted drugs;
Research on the pathogenic mechanisms and related treatment methods of various autoimmune diseases, such as rheumatoid arthritis (RA) and psoriasis;
Research on the pathogenic mechanisms and related treatment methods of inflammatory diseases, such as inflammatory bowel disease (IBD);
Research on the pathogenic mechanisms and related treatment methods of various hematological malignancies.
문의하기
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