huIL18 Mouse
제품명
huIL18 Mouse
제품 ID
C001988
품종 계통
C57BL/6NCya-Il18tm1(hIL18)/Cya
Backgroud
C57BL/6NCya
상태
이 마우스 계통을 논문에서 사용할 경우, “huIL18 Mouse (카탈로그 번호 C001988)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
유전자명
유전자 별칭
IGIF, IL-18, IL-1g, IL1F4
NCBI ID
염색체
Chr 11
MGI ID
Datasheet
품종 계통 설명
Interleukin-18 (IL18) is a pro-inflammatory cytokine primarily secreted by macrophages, dendritic cells, and keratinocytes. It is a member of the IL-1 superfamily and plays an important regulatory role in both innate and adaptive immune responses [1]. IL18 binds to the IL18 receptor (IL18R) and, in synergy with IL12, induces Th1 cells to produce interferon-γ (IFN-γ), promoting the activation and proliferation of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, while also participating in the regulation of inflammasome-mediated inflammatory responses [2-3]. The IL18 gene is located on human chromosome 11 and is closely associated with the development of various autoimmune diseases, infectious diseases, and cancers. It has emerged as an important target for tumor immunotherapy, infectious vaccine development, and drug research for autoimmune diseases [4-5].
The huIL18 mouse is a humanized model constructed by gene-editing technology, in which the sequence from the start codon to the stop codon of the mouse endogenous Il18 gene is replaced with the corresponding sequence of the human IL18 gene. This model is suitable for evaluating the efficacy and safety of IL18-targeted antibodies and CAR-cell therapies, as well as for preclinical studies in tumor immunity, infectious disease vaccines, autoimmune disorders, and metabolic and cardiovascular diseases.
Reference
Okamura H, Tsutsi H, Komatsu T, et al. Cloning of a new cytokine that induces IFN-gamma production by T cells[J]. Nature, 1995, 378(6552): 88-91.
Dinarello C A. IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family[J]. J Allergy Clin Immunol, 1999, 103(1): 11-24.
Gu Y, Kuida K, Tsutsui H, et al. Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme[J]. Science, 1997, 275(5297): 206-209.
Robertson M J, Mier J W, Logan T, et al. Clinical and biological effects of recombinant human interleukin-18 administered by intravenous infusion to patients with advanced cancer[J]. Clin Cancer Res, 2006, 12(14): 4268-4277.
Torigoe K, Ushio S, Okura T, et al. Purification and characterization of the human interleukin-18 receptor[J]. J Biol Chem, 1997, 272(41): 25737-25742.
변형 전략
The sequences from the start codon to the stop codon of the endogenous mouse Il18 gene were replaced with the sequences from the start codon to the stop codon of the human IL18 gene.
Figure 1. Gene editing strategy of huIL18 mice.
응용 분야
Research on tumor immunotherapy;
Development and evaluation of infectious disease vaccines;
Research on the mechanisms of autoimmune diseases and drug screening;
Research on metabolic and cardiovascular diseases;
Research on inflammasomes and innate immune signaling pathways;
Preclinical evaluation of IL18-targeted drugs.
문의하기
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