huIL4/huIL4R/huTSLP/hTSLPR Mouse
제품명
huIL4/huIL4R/huTSLP/hTSLPR Mouse
제품 ID
C001996
품종 계통
C57BL/6NCya-Il4em1(hIL4)Il4raem1(hIL4R)Tslpem1(hTSLP)Crlf2tm1(hCRLF2)/Cya
Backgroud
C57BL/6NCya
상태
이 마우스 계통을 논문에서 사용할 경우, “huIL4/huIL4R/huTSLP/hTSLPR Mouse (카탈로그 번호 C001996)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
유전자 별칭
BSF1, IL-4, BCGF1, BSF-1, BCGF-1, CD124, IL4RA, IL-4RA, CRL2, TSLPR, CRLF2Y
염색체
Chr 5, Chr 16, Chr X, Chr 5
MGI ID
Datasheet
품종 계통 설명
The huIL4/huIL4R/huTSLP/hTSLPR mice are a quadruple-gene humanized model obtained by mating huIL4/huIL4R mice (catalog number: C001834), huTSLP mice (catalog number: C001809), and hTSLPR mice (catalog number: C001942). This model is a valuable tool for studying allergic diseases (such as asthma and atopic dermatitis), Th2 immune responses, parasitic infections, tumor immunology, and chronic inflammation. In addition, this model also provides a powerful preclinical research platform for evaluating the efficacy and mechanism of therapeutic drugs targeting IL4/IL4R/TSLP/TSLPR.
변형 전략
The huIL4/huIL4R/huTSLP/hTSLPR mice are a quadruple-gene humanized model obtained by mating huIL4/huIL4R mice (catalog number: C001834), huTSLP mice (catalog number: C001809), and hTSLPR mice (catalog number: C001942).
Figure 1. Gene editing strategy of huIL4 mice. The sequences from the ATG start codon to the TAG stop codon of the endogenous mouse Il4 gene were replaced with the sequences from the ATG start codon to the TGA stop codon of the human IL4 gene.
Figure 2. Gene editing strategy of huIL4R mice. The extracellular domain of the mouse Il4ra was replaced with the corresponding human IL4R extracellular domain, while retaining the murine signal peptide.
Figure 3. Gene editing strategy of huTSLP mice. The mouse Tslp endogenous domain was replaced with the human TSLP domain. The murine signal peptide was preserved.
Figure 4. Gene editing strategy of hTSLPR mice. Part of exon 1 to intron 7 of Mouse Crlf2 was replaced with Human CRLF2 CDS-Mouse Crlf2 CDS cassette.
응용 분야
Screening, development and safety evaluation of IL4/IL4R/TSLP/TSLPR-targeted drugs;
Research on the pathogenic mechanisms and related treatment methods of inflammatory and allergic diseases, such as asthma and allergic rhinitis;
Research on immune regulation, parasitic infections, and tumor immunity.
문의하기
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