huGDF8/huALK7 Mouse

Figure 1. Gene editing strategy of huMSTN(GDF8) mice. The mouse Mstn genomic DNA was replaced with the human MSTN genomic DNA. The murine signal peptide was preserved.

Figure 2. Gene editing strategy for huALK7(ACVR1C) mice. The sequences from the 5’UTR to downstream of the 3’UTR of the mouse Acvr1c gene were replaced with the sequences from the 5’UTR to downstream of the 3’UTR of the human ACVR1C gene.