huTSLP/hTSLPR/huIL7R Mouse
제품명
huTSLP/hTSLPR/huIL7R Mouse
제품 ID
C002094
품종 계통
C57BL/6Cya-Tslpem1(hTSLP)Crlf2tm1(hCRLF2)Il7rem1(hIL7R)/Cya
Backgroud
C57BL/6Cya
상태
이 마우스 계통을 논문에서 사용할 경우, “huTSLP/hTSLPR/huIL7R Mouse (카탈로그 번호 C002094)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
유전자 별칭
ILRA, CD127, IL7RA, CDW127, IMD104, sIL-7R, lnc-IL7R, IL7Ralpha, IL-7Ralpha, IL-7R-alpha, CRL2, TSLPR, CRLF2Y
염색체
Chr 5, Chr X, Chr 5
MGI ID
Datasheet
품종 계통 설명
TSLP (thymic stromal lymphopoietin) is a cytokine involved in the initiation of immune responses and the regulation of allergic inflammation [1-2]; TSLPR (thymic stromal lymphopoietin receptor), encoded by the CRLF2 gene, forms a TSLP receptor complex with IL-7Rα (interleukin-7 receptor alpha), which can bind the ligand TSLP [3]; IL7R encodes IL-7Rα, which is involved in lymphocyte survival, proliferation, differentiation, and the maintenance of immune homeostasis [4]. Based on this ligand–receptor relationship, the combined design of humanized TSLP, TSLPR, and IL7R can be utilized to study immune regulation associated with TSLP–TSLPR/IL7R from the perspective of the ligand and receptor complex components.
The huTSLP/hTSLPR/huIL7R mouse is a triple-gene humanized model obtained by crossing the huTSLP mouse (Catalog No.: C001809), the hTSLPR mouse (Catalog No.: C001942), and the huIL7R mouse (Catalog No.: C001633). The huTSLP/hTSLPR/huIL7R mouse incorporates a combined design involving humanized TSLP, TSLPR, and IL7R and can be utilized for studies of immune regulation associated with the TSLP–TSLPR/IL-7R receptor complex, including JAK/STAT and PI3K/AKT/mTOR signaling regulation; studies of inflammatory and allergic diseases including asthma and allergic rhinitis; and the screening, development, pharmacodynamic evaluation, and safety assessment of related targeted therapeutics.
Reference
Parnes JR, Molfino NA, Colice G, Martin U, Corren J, Menzies-Gow A. Targeting TSLP in Asthma. J Asthma Allergy. 2022 Jun 3;15:749-765.
Nakajima S, Kabata H, Kabashima K, Asano K. Anti-TSLP antibodies: Targeting a master regulator of type 2 immune responses. Allergol Int. 2020 Apr;69(2):197-203.
Tasian SK, Loh ML. Understanding the biology of CRLF2-overexpressing acute lymphoblastic leukemia. Crit Rev Oncog. 2011;16(1-2):13-24.
Barata JT, Durum SK, Seddon B. Flip the coin: IL-7 and IL-7R in health and disease. Nat Immunol. 2019 Dec;20(12):1584-1593.
변형 전략
The huTSLP/hTSLPR/huIL7R mouse is a triple-gene humanized model obtained by crossing the huTSLP mouse (Catalog No.: C001809), the hTSLPR mouse (Catalog No.: C001942), and the huIL7R mouse (Catalog No.: C001633).
Figure 1. Gene editing strategy of huTSLP mice. The mouse Tslp endogenous domain was replaced with the human TSLP domain. The murine signal peptide was preserved.
Figure 2. Gene editing strategy of hTSLPR mice. Part of exon 1 to intron 7 of Mouse Crlf2 was replaced with Human CRLF2 CDS-Mouse Crlf2 CDS cassette.
Figure 3. Gene editing strategy of huIL7R mice. The mouse Il7r endogenous extracellular domain was replaced with the human IL7R extracellular domain. The murine IL7R signal peptide and cytoplasmic region was preserved.
응용 분야
Studies of immune regulatory mechanisms associated with TSLP–TSLPR/IL-7R, including JAK/STAT and PI3K/AKT/mTOR signaling regulation;
Studies of inflammatory and allergic diseases including asthma and allergic rhinitis;
Screening, development, pharmacodynamic evaluation, and safety assessment of therapeutics targeting TSLP, TSLPR, and IL7R.
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