hSCN9A Mouse
제품명
hSCN9A Mouse
제품 ID
C002105
품종 계통
C57BL/6NCya-Scn9atm2(hSCN9A)/Cya
Backgroud
C57BL/6NCya
상태
이 마우스 계통을 논문에서 사용할 경우, “hSCN9A Mouse (카탈로그 번호 C002105)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
유전자명
유전자 별칭
PN1, ETHA, NENA, SFNP, FEB3B, NE-NA, GEFSP7, HSAN2D, Nav1.7
NCBI ID
염색체
Chr 2
MGI ID
Datasheet
품종 계통 설명
The SCN9A gene encodes the sodium channel protein Nav1.7 and is closely associated with peripheral neuropathic pain and several related rare genetic disorders. The Nav1.7 sodium channel mediates the flow of sodium ions across the cell membrane and plays an important role in the generation and transmission of electrical signals in neurons. Studies have shown that genetic variants in SCN9A are closely associated with several inherited pain disorders, including inherited erythromelalgia (IEM), small fiber neuropathy (SFN), and congenital insensitivity to pain (CIP) [1-2]. As a voltage-gated sodium channel, Nav1.7 is mainly expressed in sensory and sympathetic neurons of the peripheral nervous system and is highly expressed in the dorsal root ganglia (DRG), where it plays a critical role in the generation and transmission of pain signals [3]. Studies have suggested that downregulation of SCN9A expression or selective inhibition of Nav1.7 may represent a potential analgesic strategy for investigating acute, inflammatory, and neuropathic pain [4].
The hSCN9A Mouse is a humanized Scn9a model. The coding sequences of exon 2 plus partial intron 2 of mouse Scn9a were replaced with the Kozak-Human SCN9A CDS-3'UTR of Human SCN9A-WPRE-BGH pA cassette. Its applications mainly include mechanistic studies of inherited erythromelalgia (IEM), small fiber neuropathy (SFN), congenital insensitivity to pain (CIP), and SCN9A-associated epileptic encephalopathies, as well as the exploration of therapeutic strategies targeting human Nav1.7. This model may be used to evaluate the potential effects of Nav1.7 inhibitors, antisense nucleic acid-based approaches, and gene therapies and to support drug screening and pharmacological evaluation for SCN9A-related disorders.
Reference
Ghanty I, Perez-Palma E, Villaman C, et al. SCN9A should not be considered an epilepsy gene; Refuting a gene-disease association. Epilepsia. 2025;66(9):3516-3527.
Gomez K, Stratton HJ, Duran P, et al. Identification and targeting of a unique NaV1.7 domain driving chronic pain. Proc Natl Acad Sci U S A. 2023;120(32):e2217800120.
Waxman SG. NaV1.7: A central role in pain. Neuron. 2023;111(17):2615-2617.
Sutemieva JA, Sobenin DV. Voltage-gated sodium channels in pain: Which channels, which blockers, and where NaV1.7 fits. Prog Biophys Mol Biol. 2026;200:138-162.
변형 전략
The coding sequences of exon 2 plus partial intron 2 of mouse Scn9a were replaced with the Kozak-Human SCN9A CDS-3'UTR of Human SCN9A-WPRE-BGH pA cassette.
Figure 1. Gene editing strategy of hSCN9A mice.
응용 분야
Analgesic Drug Screening: Used to evaluate the potential analgesic effects and safety of therapeutic strategies targeting human Nav1.7, including small-molecule inhibitors, antisense PNA approaches such as OLP-1002, and gene therapies;
Mechanistic Studies of Inherited Erythromelalgia (IEM): Used to investigate the mechanisms associated with gain-of-function variants of human Nav1.7 in inherited erythromelalgia (IEM) and to explore potential therapeutic strategies;
Congenital Insensitivity to Pain (CIP) Studies: Used to investigate the mechanisms associated with loss-of-function variants of human Nav1.7 in congenital insensitivity to pain (CIP), as well as the molecular mechanisms underlying impaired pain signal transmission;
Small Fiber Neuropathy (SFN) Studies: Used to investigate the pathological mechanisms of SCN9A variant-associated small fiber neuropathy (SFN) and to explore potential therapeutic targets;
SCN9A-Associated Epilepsy and Epileptic Encephalopathy Studies: Used to investigate the mechanisms associated with SCN9A variants in epilepsy and epileptic encephalopathies and to explore the potential role of Nav1.7 in related neurological disorders.
문의하기
맞춤형 동물 모델 관련 상담을 위해 Cyagen 전문가와 연락해 보세요. 아래 양식을 작성하여 상담을 시작하거나 견적을 요청하시기 바랍니다.
Cyagen은 고객님의 개인정보를 소중히 여깁니다. 최신 제품, 서비스 및 인사이트를 안내드리고자 합니다. 고객님의 수신 설정은 다음과 같습니다:
해당 커뮤니케이션은 언제든지 수신 거부하실 수 있습니다. 수신 거부 방법 및 데이터 보호에 대한 자세한 내용은 개인정보처리방침을 참고해 주시기 바랍니다.
아래 버튼을 클릭함으로써, 요청하신 콘텐츠 제공을 위해 본 양식을 통해 제출된 개인정보를 Cyagen이 저장 및 처리하는 데 동의하게 됩니다.