Adgrb1-flox Mouse

Adgrb1, also known as BAI1, is an adhesion G protein-coupled receptor. It plays significant roles in suppressing angiogenesis, mediating phagocytosis, and acting as a brain tumor suppressor. It is also crucial for dendritic spine and excitatory synapse development, interacting with autism-relevant proteins. It may be involved in pathways related to synaptic function, axon guidance, and synapse assembly [1,2].

In Adgrb1 mutant mice, homozygous (Adgrb1-/-) mice show significant social behavior deficits, increased seizure susceptibility, delayed growth, reduced brain weight, reduced neuron density, and increased apoptosis in the hippocampus during brain development [2]. Additionally, a genetic variant near Adgrb1, rs4129585, may regulate Adgrb1 and is associated with schizophrenia risk, as genes related to its alleles are interconnected in synaptic-related pathways [3,4].

In conclusion, Adgrb1 is essential for multiple biological processes, especially those related to brain development and function. The study of Adgrb1 using gene-knockout mouse models has revealed its significance in social behavior, seizure susceptibility, and brain morphology, as well as its potential association with schizophrenia. These findings contribute to understanding the biological functions of Adgrb1 and its implications in related diseases.