Cbr3-flox Mouse
Common Name
Cbr3-flox
제품 ID
S-CKO-00807
Backgroud
C57BL/6JCya
품종 계통계통 ID
CKOCMP-109857-Cbr3-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Cbr3-flox Mouse (카탈로그 번호 S-CKO-00807)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Cbr3-flox
품종 계통계통 ID
CKOCMP-109857-Cbr3-B6J-VA
유전자명
제품 ID
S-CKO-00807
유전자 별칭
1110001J05Rik
배경
C57BL/6JCya
NCBI ID
변형 내용
Conditional knockout
염색체
Chr 16
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000039620
NCBI 전사체 ID
NM_173047
타겟 영역
Exon 3
유효 영역 크기
~1.6 kb
유전자 연구 개요
Cbr3, also known as carbonyl reductase 3, is involved in various biological processes and diseases. Its single nucleotide polymorphism (V244M) has been linked to the risk of anthracycline-related cardiomyopathy, with the CBR3 V244M genotype status associated with changes in echocardiographic parameters suggestive of early anthracycline-related cardiomyopathy in breast cancer patients undergoing chemotherapy [5].
The long non-coding RNA CBR3-AS1, which is related to Cbr3, has been found to play oncogenic roles in multiple cancers. In gestational choriocarcinoma, it accelerates malignant proliferation by stabilizing SETD4 [1]. In osteosarcoma, it promotes stemness, EMT, and tumor growth through the miR-140-5p/DDX54-NUCKS1-mTOR signaling pathway [2]. In cervical cancer, high expression of CBR3-AS1 predicts poor prognosis and promotes cancer progression through the miR-3163/LASP1 pathway [4]. In lung adenocarcinoma, it potentiates Wnt/β-catenin signaling to regulate cell proliferation, migration, and invasion [6]. In colorectal cancer, it promotes stem-like properties and oxaliplatin resistance by sponging miR-145-5p [7]. In breast cancer, it regulates drug sensitivity as a competing endogenous RNA through the JNK1/MEK4-mediated MAPK signal pathway [8]. In ulcerative colitis, it promotes and enhances malignancy by targeting miRNA-145-5p/FN1 [3]. Additionally, allicin affects the immunoreactivity of osteosarcoma cells through the CBR3-AS1/miR-145-5p/GRP78 axis [9].
In conclusion, Cbr3 and its related lncRNA CBR3-AS1 are involved in multiple biological processes and play important roles in various diseases, especially in cancer progression and drug-related cardiotoxicity. Studies on these genes help to understand the mechanisms of disease occurrence and may provide new strategies for treatment.
References：
1. Zhang, Yajuan, Zhang, Hongxiu, Zhang, Xiaolei, Liu, Bin. 2022. CBR3-AS1 Accelerates the Malignant Proliferation of Gestational Choriocarcinoma Cells by Stabilizing SETD4. In Disease markers, 2022, 7155525. doi:10.1155/2022/7155525. https://pubmed.ncbi.nlm.nih.gov/35655916/
2. Yao, Weitao, Hou, Jingyu, Liu, Guoqing, Guo, Liangyu, Wang, Chuchu. 2022. LncRNA CBR3-AS1 promotes osteosarcoma progression through the network of miR-140-5p/DDX54-NUCKS1-mTOR signaling pathway. In Molecular therapy oncolytics, 25, 189-200. doi:10.1016/j.omto.2022.03.001. https://pubmed.ncbi.nlm.nih.gov/35592388/
3. Cao, Jingmei, Zhao, Qing, Jia, Qing, Li, Yiming. 2023. LncRNA-CBR3-AS1 promotes and enhances the malignancy of ulcerative colitis via targeting miRNA-145-5p/FN1. In Cellular and molecular biology (Noisy-le-Grand, France), 69, 181-186. doi:10.14715/cmb/2023.69.7.29. https://pubmed.ncbi.nlm.nih.gov/37715388/
4. Cai, Yipin, Huang, Yu, Zhang, Jie, Huang, Haiwei, Gao, Yu. . LncRNA CBR3-AS1 predicts a poor prognosis and promotes cervical cancer progression through the miR-3163/LASP1 pathway. In Neoplasma, 69, 1406-1417. doi:10.4149/neo_2022_220730N784. https://pubmed.ncbi.nlm.nih.gov/36591804/
5. Lang, Jennifer K, Karthikeyan, Badri, Quiñones-Lombraña, Adolfo, Blanco, Javier G, O'Connor, Tracey. 2021. CBR3 V244M is associated with LVEF reduction in breast cancer patients treated with doxorubicin. In Cardio-oncology (London, England), 7, 17. doi:10.1186/s40959-021-00103-0. https://pubmed.ncbi.nlm.nih.gov/33975650/
6. Hou, Min, Wu, Nannan, Yao, Lili. 2021. LncRNA CBR3-AS1 potentiates Wnt/β-catenin signaling to regulate lung adenocarcinoma cells proliferation, migration and invasion. In Cancer cell international, 21, 36. doi:10.1186/s12935-020-01685-y. https://pubmed.ncbi.nlm.nih.gov/33422081/
7. Xie, Liangbao, Cui, Guangfei, Li, Tao. 2022. Long Noncoding RNA CBR3-AS1 Promotes Stem-like Properties and Oxaliplatin Resistance of Colorectal Cancer by Sponging miR-145-5p. In Journal of oncology, 2022, 2260211. doi:10.1155/2022/2260211. https://pubmed.ncbi.nlm.nih.gov/35466320/
8. Zhang, Ming, Wang, Yan, Jiang, Longyang, Wei, Minjie, Zhao, Lin. 2021. LncRNA CBR3-AS1 regulates of breast cancer drug sensitivity as a competing endogenous RNA through the JNK1/MEK4-mediated MAPK signal pathway. In Journal of experimental & clinical cancer research : CR, 40, 41. doi:10.1186/s13046-021-01844-7. https://pubmed.ncbi.nlm.nih.gov/33494806/
9. Xie, Wenpeng, Ma, Fengjun, Dou, Luming, Zhang, Zhimeng, Zhang, Yongkui. 2024. Allicin affects immunoreactivity of osteosarcoma cells through lncRNA CBR3-AS1. In Heliyon, 10, e31971. doi:10.1016/j.heliyon.2024.e31971. https://pubmed.ncbi.nlm.nih.gov/38947424/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
Cyagen문의하기
맞춤형 동물 모델 관련 상담을 위해 Cyagen 전문가와 연락해 보세요. 아래 양식을 작성하여 상담을 시작하거나 견적을 요청하시기 바랍니다.
Cyagen은 고객님의 개인정보를 소중히 여깁니다. 최신 제품, 서비스 및 인사이트를 안내드리고자 합니다. 고객님의 수신 설정은 다음과 같습니다:
해당 커뮤니케이션은 언제든지 수신 거부하실 수 있습니다. 수신 거부 방법 및 데이터 보호에 대한 자세한 내용은 개인정보처리방침을 참고해 주시기 바랍니다.
아래 버튼을 클릭함으로써, 요청하신 콘텐츠 제공을 위해 본 양식을 통해 제출된 개인정보를 Cyagen이 저장 및 처리하는 데 동의하게 됩니다.