Adra1a-flox Mouse

Adra1a, also known as the alpha-1A adrenergic receptor, is a crucial component in the adrenergic signaling pathway. It is involved in multiple physiological processes. Noradrenaline-induced ADRA1A-Gαq signalling promotes adipocyte thermogenesis through the effector proteins of the futile creatine cycle, creatine kinase B and tissue-non-specific alkaline phosphatase, highlighting its role in energy metabolism [1].

In a pregnancy-associated hypertensive (PAH) mouse model, Adra1a -deficient PAH mice exhibited more severe cardiac hypertrophy than PAH mice, suggesting that changes in Adra1a expression are involved in progressive cardiac hypertrophy in PAH mice as Adra1a levels are regulated by the renin-angiotensin system [2].

In summary, Adra1a plays essential roles in adipocyte thermogenesis and cardiac hypertrophy regulation. Gene-knockout mouse models, like the Adra1a -deficient mice in the PAH model, have provided valuable insights into its functions in disease-related biological processes, especially in energy metabolism and heart-related diseases.