Bex2-flox Mouse
Common Name
Bex2-flox
제품 ID
S-CKO-01411
Backgroud
C57BL/6JCya
품종 계통계통 ID
CKOCMP-12069-Bex2-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Bex2-flox Mouse (카탈로그 번호 S-CKO-01411)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Bex2-flox
품종 계통계통 ID
CKOCMP-12069-Bex2-B6J-VA
유전자명
제품 ID
S-CKO-01411
유전자 별칭
Bex1, REX-3
배경
C57BL/6JCya
NCBI ID
변형 내용
Conditional knockout
염색체
Chr X
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000049130
NCBI 전사체 ID
NM_009749
타겟 영역
Exon 3
유효 영역 크기
~1.9 kb
유전자 연구 개요
Bex2, or Brain Expressed X-linked gene 2, was originally identified for promoting transcription by interacting with transcription factors in DNA-binding complexes. It is involved in multiple cellular processes and associated with several signaling pathways such as NF-κB, c-Jun/JNK, and ErbB2 pathways [2]. Bex2 has been shown to play a significant role in carcinogenesis, making it biologically important in understanding cancer development [2]. Genetic models like gene knockout (KO) could potentially be valuable in further elucidating its functions.
Knockdown of Bex2 in various cancer cell lines has revealed its role in cancer-related processes. In lung cancer cells, crotonylated Bex2 enhances mitophagy by facilitating the interaction between NDP52 and LC3B, and its overexpression inhibits chemotherapy-induced apoptosis [1]. In breast, colorectal, hepatocellular cancers, and brain tumors, Bex2 promotes cell growth, survival, migration, and invasion, and regulates apoptosis and the cell cycle through cross-talk with relevant signaling pathways [2]. In gastric and hepatocellular carcinomas, Bex2 is associated with cancer stemness and poor prognosis, and its knockdown decreases stem-like properties and increases drug sensitivity [3,4]. In colorectal cancer, Bex2 promotes cell proliferation via the JNK/c-Jun pathway [5]. In intrahepatic cholangiocarcinoma, Bex2 is essential for maintaining dormant cancer stem cells by suppressing mitochondrial activity [6]. In glioma cells, Bex2 promotes migration and invasion, likely mediated by N-cadherin and MMP-2 [7].
In conclusion, Bex2 is a gene with diverse functions in cancer biology, mainly promoting cancer-related processes such as cell growth, survival, migration, and invasion, and is associated with cancer stemness and poor prognosis in multiple cancer types. The use of knockdown and overexpression models in various cancer cell lines has significantly contributed to understanding Bex2's role in these disease conditions, providing potential therapeutic targets for cancer treatment.
References：
1. Mu, Ning, Wang, Yu, Li, Xiaopeng, Su, Ling, Liu, Xiangguo. 2023. Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells. In Cell death & disease, 14, 645. doi:10.1038/s41419-023-06164-6. https://pubmed.ncbi.nlm.nih.gov/37777549/
2. Naderi, Ali. 2019. Molecular functions of brain expressed X-linked 2 (BEX2) in malignancies. In Experimental cell research, 376, 221-226. doi:10.1016/j.yexcr.2019.02.014. https://pubmed.ncbi.nlm.nih.gov/30779920/
3. Yasumoto, Akihiro, Fujimori, Haruna, Mochizuki, Mai, Shibata, Chikashi, Tamai, Keiichi. 2023. BEX2 is poor prognostic factor and required for cancer stemness in gastric cancer. In Biochemical and biophysical research communications, 655, 59-67. doi:10.1016/j.bbrc.2023.03.025. https://pubmed.ncbi.nlm.nih.gov/36933308/
4. Fukushi, Daisuke, Shibuya-Takahashi, Rie, Mochizuki, Mai, Satoh, Kennichi, Tamai, Keiichi. 2021. BEX2 is required for maintaining dormant cancer stem cell in hepatocellular carcinoma. In Cancer science, 112, 4580-4592. doi:10.1111/cas.15115. https://pubmed.ncbi.nlm.nih.gov/34424582/
5. Hu, Yeting, Xiao, Qian, Chen, Haiyan, Yuan, Ying, Ding, Kefeng. 2017. BEX2 promotes tumor proliferation in colorectal cancer. In International journal of biological sciences, 13, 286-294. doi:10.7150/ijbs.15171. https://pubmed.ncbi.nlm.nih.gov/28367093/
6. Tamai, Keiichi, Nakamura-Shima, Mao, Shibuya-Takahashi, Rie, Sugamura, Kazuo, Satoh, Kennichi. 2020. BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma. In Scientific reports, 10, 21592. doi:10.1038/s41598-020-78539-0. https://pubmed.ncbi.nlm.nih.gov/33299012/
7. Zhou, Xiuping, Xu, Xuebin, Meng, Qingming, Shi, Qiong, Yu, Rutong. 2012. Bex2 is critical for migration and invasion in malignant glioma cells. In Journal of molecular neuroscience : MN, 50, 78-87. doi:10.1007/s12031-012-9864-8. https://pubmed.ncbi.nlm.nih.gov/22907646/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
Cyagen문의하기
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