Csrp1-flox Mouse
Common Name
Csrp1-flox
제품 ID
S-CKO-01922
Backgroud
C57BL/6JCya
품종 계통계통 ID
CKOCMP-13007-Csrp1-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Csrp1-flox Mouse (카탈로그 번호 S-CKO-01922)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Csrp1-flox
품종 계통계통 ID
CKOCMP-13007-Csrp1-B6J-VA
유전자명
제품 ID
S-CKO-01922
유전자 별칭
CRP1, Csrp
배경
C57BL/6JCya
NCBI ID
변형 내용
Conditional knockout
염색체
Chr 1
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000097561
NCBI 전사체 ID
NM_001360782
타겟 영역
Exon 3~4
유효 영역 크기
~2.7 kb
유전자 연구 개요
Csrp1, also known as Cysteine and Glycine-Rich Protein 1, belongs to the cysteine-rich protein family and contains a unique double-zinc finger motif. It is important for development and cellular differentiation, and is a marker of smooth muscle lineages. Csrp1 interacts with Dishevelled 2 and Diversin, controlling cell morphology and other dynamic cell behaviors via the noncanonical Wnt and JNK pathways [5].
In colon cancer, lower Csrp1 expression is noted in tumors compared to normal colon tissue, yet patients with high Csrp1 expression have shorter recurrence-free, overall, and disease-specific survivals. Its expression is positively correlated with mesenchymal markers, EMT score, and stromal score, and is associated with CMS4 colon tumors. In colon adenocarcinoma, higher Csrp1 expression is correlated with worse prognosis and can promote tumor growth and migration [1,2].
In acute myeloid leukemia, Csrp1 shows notable expression variations between normal and tumor samples, is an independent prognostic factor, and correlates with immune-related pathways, immune cells, and immune checkpoints. Also, the METTL3/YTHDF1 axis stabilizes Csrp1 mRNA to regulate glycolysis and promote AML progression [3,4].
In hormone-sensitive prostate cancer, low Csrp1 expression promotes the advancement towards castration-resistant prostate cancer, making its expression level a potential biomarker [6].
In neuroblastoma, Csrp1 is involved in differentiation, apoptosis, and possibly innate immunity, and can enhance the effects of certain combination therapies [7].
In conclusion, Csrp1 is crucial for development and cellular differentiation, playing significant roles in multiple diseases such as colon cancer, acute myeloid leukemia, prostate cancer, and neuroblastoma. Functional studies, especially those related to its expression levels and associated pathways in these diseases, provide insights into its functions. Research on Csrp1 helps in understanding disease mechanisms and may offer new strategies for disease treatment.
References：
1. Demirkol Canli, Seçil. 2023. CSRP1 expression is associated with a mesenchymal, stroma-rich tumor profile and poor prognosis in colon cancer. In Turkish journal of medical sciences, 53, 1678-1689. doi:10.55730/1300-0144.5736. https://pubmed.ncbi.nlm.nih.gov/38813484/
2. Yu, Senlong, Zhao, Haifeng, Meng, Hongjie, Bian, Tianhua, Ruan, Canping. 2023. CSRP1 Promotes Colon Adenocarcinoma Growth and Serves as an Independent Risk Biomarker for Worse Prognosis. In Genetics research, 2023, 8586507. doi:10.1155/2023/8586507. https://pubmed.ncbi.nlm.nih.gov/37113556/
3. Zhao, Chunxia, Wang, Yulu, Wang, Huan, Schmidt-Wolf, Ingo G H, Wang, Zifeng. 2024. CSRP1 gene: a potential novel prognostic marker in acute myeloid leukemia with implications for immune response. In Discover oncology, 15, 248. doi:10.1007/s12672-024-01088-9. https://pubmed.ncbi.nlm.nih.gov/38937285/
4. Han, Lili, Wang, Ruiyan, He, Mengyu, Chen, Zhenyue, Wang, Feng. 2024. METTL3/YTDHF1 Stabilizes CSRP1 mRNA to Regulate Glycolysis and Promote Acute Myeloid Leukemia Progression. In Cell biochemistry and biophysics, , . doi:10.1007/s12013-024-01610-4. https://pubmed.ncbi.nlm.nih.gov/39565517/
5. Miyasaka, Kota Y, Kida, Yasuyuki S, Sato, Takayuki, Minami, Mari, Ogura, Toshihiko. 2007. Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin. In Proceedings of the National Academy of Sciences of the United States of America, 104, 11274-9. doi:. https://pubmed.ncbi.nlm.nih.gov/17592114/
6. Pan, Chenxi, Wang, Wei, He, Yi, Yang, Bo. 2025. Identification of CSRP1 as novel biomarker for hormone-sensitive prostate cancer by the combination of clinical and functional research. In Cancer cell international, 25, 65. doi:10.1186/s12935-025-03708-y. https://pubmed.ncbi.nlm.nih.gov/39994616/
7. Lin, Yu-Han, Jiang, Jyun-Hong, Chuang, Hui-Ching, Lian, Wei-Shiung, Chuang, Jiin-Haur. . The Involvement of CSRP1 in Neuroblastoma Differentiation and Apoptosis Impacting Tumor-Suppressive Therapeutic Responses. In FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 39, e70521. doi:10.1096/fj.202500403R. https://pubmed.ncbi.nlm.nih.gov/40198006/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
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