Hsph1-flox Mouse
Common Name
Hsph1-flox
제품 ID
S-CKO-02991
Backgroud
C57BL/6JCya
품종 계통계통 ID
CKOCMP-15505-Hsph1-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Hsph1-flox Mouse (카탈로그 번호 S-CKO-02991)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Hsph1-flox
품종 계통계통 ID
CKOCMP-15505-Hsph1-B6J-VA
유전자명
제품 ID
S-CKO-02991
유전자 별칭
105kDa, Hsp105, Hsp110, hsp-E7I, hsp110/105
배경
C57BL/6JCya
NCBI ID
변형 내용
Conditional knockout
염색체
Chr 5
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000202361
NCBI 전사체 ID
NM_013559
타겟 영역
Exon 2
유효 영역 크기
~2.1 kb
유전자 연구 개요
HSPH1, also known as heat shock 105kDa/110kDa protein 1, is a member of the heat shock protein family. Heat shock proteins play crucial roles in maintaining protein homeostasis, such as preventing protein aggregation, assisting in protein folding, and participating in stress response pathways [5,8].
In cancer research, HSPH1 has been implicated in multiple types of cancers. In gastric cancer, it was identified as a target of ATF2. HSPH1 can interact with SLC7A11 to increase its protein stability, and knockdown of HSPH1 partly reversed the inhibitory effect of ATF2 overexpression on sorafenib-induced ferroptosis [1]. In advanced lung adenocarcinoma, the rs2280059 genetic variant of HSPH1 modulated its expression, and silencing HSPH1 significantly increased the antineoplastic effects of gefitinib [2]. In aggressive B-cell non-Hodgkin lymphoma, HSPH1 silencing downregulated Bcl-6 and c-Myc, hampering the growth of lymphoma cells both in vitro and in vivo [6]. In prostate cancer, HSPH1 may promote the differentiation of conventional T cells towards Th1 or Th2 cells, increase CD8 + T cells in the tumor area, and inhibit prostate cancer invasion [3]. In addition, in N-methyl-N-nitrosourea-induced gastric carcinogenesis, YTHDF1 regulated the translation of HSPH1, affecting malignant transformation and tumorigenesis [4].
In acute lung injury, the IL-1β/KLF2/HSPH1 pathway was activated, facilitating STAT3 phosphorylation in alveolar macrophages and exacerbating pulmonary inflammation [7]. Also, HSPH1 was found as a potential biomarker in doxorubicin-induced chronic cardiotoxicity [9].
In conclusion, HSPH1 is an important gene involved in protein-related cellular functions and stress responses. Its dysregulation is associated with various diseases, especially cancers. Studies using gene-knockdown or other loss-of-function models have revealed its roles in promoting cancer cell growth, drug resistance, and influencing disease-related signaling pathways, providing potential therapeutic targets for these diseases.
References：
1. Xu, Xin, Li, Yaxian, Wu, Youliang, Wang, Huizhen, Li, Yongxiang. 2022. Increased ATF2 expression predicts poor prognosis and inhibits sorafenib-induced ferroptosis in gastric cancer. In Redox biology, 59, 102564. doi:10.1016/j.redox.2022.102564. https://pubmed.ncbi.nlm.nih.gov/36473315/
2. Li, Yankang, Zhang, Nasha, Zhang, Li, Yu, Jinming, Yang, Ming. . Oncogene HSPH1 modulated by the rs2280059 genetic variant diminishes EGFR-TKIs efficiency in advanced lung adenocarcinoma. In Carcinogenesis, 41, 1195-1202. doi:10.1093/carcin/bgaa069. https://pubmed.ncbi.nlm.nih.gov/32815538/
3. Wu, Xinrui, Zhu, Yinjie, Hu, Cong, Dong, Liang, Pan, Jiahua. 2024. Extracellular vesicles related gene HSPH1 exerts anti-tumor effects in prostate cancer via promoting the stress response of CD8 + T cells. In Cellular oncology (Dordrecht, Netherlands), 47, 1059-1064. doi:10.1007/s13402-023-00905-7. https://pubmed.ncbi.nlm.nih.gov/38165608/
4. Song, Peng, Li, Xiang, Chen, Shuai, He, Jian, Tang, Liming. 2024. YTHDF1 mediates N-methyl-N-nitrosourea-induced gastric carcinogenesis by controlling HSPH1 translation. In Cell proliferation, 57, e13619. doi:10.1111/cpr.13619. https://pubmed.ncbi.nlm.nih.gov/38444279/
5. Robichaud, Sabrina, Fairman, Garrett, Vijithakumar, Viyashini, Baetz, Kristin, Ouimet, Mireille. 2021. Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells. In Autophagy, 17, 3671-3689. doi:10.1080/15548627.2021.1886839. https://pubmed.ncbi.nlm.nih.gov/33590792/
6. Zappasodi, Roberta, Ruggiero, Giusi, Guarnotta, Carla, Pupa, Serenella M, Di Nicola, Massimo. 2015. HSPH1 inhibition downregulates Bcl-6 and c-Myc and hampers the growth of human aggressive B-cell non-Hodgkin lymphoma. In Blood, 125, 1768-71. doi:10.1182/blood-2014-07-590034. https://pubmed.ncbi.nlm.nih.gov/25573990/
7. Liang, Yafeng, Luo, Jiaqi, Yang, Nengli, Ye, Mingwei, Pan, Guoquan. . Activation of the IL-1β/KLF2/HSPH1 pathway promotes STAT3 phosphorylation in alveolar macrophages during LPS-induced acute lung injury. In Bioscience reports, 40, . doi:10.1042/BSR20193572. https://pubmed.ncbi.nlm.nih.gov/32091104/
8. Franco, Juliana C, Nogueira, Maria L C, Gandelini, Gabriela M, Young, Jason C, Ramos, Carlos H I. . Sorghum bicolor SbHSP110 has an elongated shape and is able of protecting against aggregation and replacing human HSPH1/HSP110 in refolding and disaggregation assays. In Biopolymers, 114, e23532. doi:10.1002/bip.23532. https://pubmed.ncbi.nlm.nih.gov/36825649/
9. Qian, Hongyan, Qian, Yi, Liu, Yi, Liu, Huanxin, Zhu, Weizhong. 2023. Identification of novel biomarkers involved in doxorubicin-induced acute and chronic cardiotoxicity, respectively, by integrated bioinformatics. In Frontiers in cardiovascular medicine, 9, 996809. doi:10.3389/fcvm.2022.996809. https://pubmed.ncbi.nlm.nih.gov/36712272/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
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