Itgal-flox Mouse
Common Name
Itgal-flox
제품 ID
S-CKO-03157
Backgroud
C57BL/6JCya
품종 계통계통 ID
CKOCMP-16408-Itgal-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Itgal-flox Mouse (카탈로그 번호 S-CKO-03157)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Itgal-flox
품종 계통계통 ID
CKOCMP-16408-Itgal-B6J-VA
유전자명
제품 ID
S-CKO-03157
유전자 별칭
Cd11a, LFA-1, Ly-15, Ly-21, (p180), LFA-1A
배경
C57BL/6JCya
NCBI ID
변형 내용
Conditional knockout
염색체
Chr 7
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000106306
NCBI 전사체 ID
NM_001253872
타겟 영역
Exon 5~7
유효 영역 크기
~1.8 kb
유전자 연구 개요
Itgal, also known as Integrin subunit alpha L, encodes an integrin component of LFA-1 and is a membrane receptor molecule widely expressed on leukocytes. It plays a key role in the interaction between white blood cells and other cells, and is involved in immune-related processes [1,2,3,5,6,7,8].
In various cancers, Itgal shows different expression patterns and associations. In non-small-cell lung cancer (NSCLC), its down-regulation in tumor tissues is associated with poor prognosis, and high Itgal expression is related to increased infiltration of CD8+ T cells, CD68+ macrophages, CD4+ T cells, and CD20+ B cells, as well as better outcomes in patients with immune checkpoint inhibitor therapy [1]. In acute myeloid leukemia, high Itgal expression is linked to poor prognosis, and it is associated with age, cytogenetic risk classifications, MDSCs, macrophages, and most immune checkpoint genes and cytokines [2]. In gastric cancer, Itgal expression is increased in cancer samples, related to poor survival, and connected with immunomodulators, chemokines, and infiltrating levels of multiple immune cell types [3]. In melanoma, it is investigated for its relationship with immune infiltration and prognosis [4]. In lung adenocarcinoma, high Itgal expression is an independent predictor of better prognosis, and it suppresses malignant progression [7]. In NSCLC, low Itgal expression is related to poorer prognosis and increased malignancy, and its co-expressed genes are associated with immune-related signaling pathways [8]. In murine low-grade glioma, Itgal/CD11A in glioma-associated microglia is critical for CX3CL1 receptor expression, CX3CL1-directed motility, and glioma mitogen production, and antibody-mediated CD11a inhibition reduces tumor growth in vivo [9].
In conclusion, Itgal is crucial in immune-cell interactions. Studies, especially those using in vivo models like the murine models in low-grade glioma research, have revealed its diverse roles in cancer development, prognosis, and immune-microenvironment regulation, providing potential directions for targeted anti-tumor strategies [9].
References：
1. Zhang, Ruihao, Zhu, Guangsheng, Li, Zaishan, Liu, Hongyu, Chen, Jun. 2024. ITGAL expression in non-small-cell lung cancer tissue and its association with immune infiltrates. In Frontiers in immunology, 15, 1382231. doi:10.3389/fimmu.2024.1382231. https://pubmed.ncbi.nlm.nih.gov/38646528/
2. Li, Ran, Wu, Xiaolu, Xue, Kai, Li, Junmin. 2022. ITGAL infers adverse prognosis and correlates with immunity in acute myeloid leukemia. In Cancer cell international, 22, 268. doi:10.1186/s12935-022-02684-x. https://pubmed.ncbi.nlm.nih.gov/35999614/
3. Zhang, Junchang, Wang, Han, Yuan, Cheng, Zhang, Changhua, He, Yulong. 2022. ITGAL as a Prognostic Biomarker Correlated With Immune Infiltrates in Gastric Cancer. In Frontiers in cell and developmental biology, 10, 808212. doi:10.3389/fcell.2022.808212. https://pubmed.ncbi.nlm.nih.gov/35399517/
4. Deng, TengFei, Wang, Chaoyong, Gao, Cong, Zhang, Qiang, Guo, Jun. 2023. ITGAL as a prognostic biomarker correlated with immune infiltrates in melanoma. In Frontiers in oncology, 13, 1181537. doi:10.3389/fonc.2023.1181537. https://pubmed.ncbi.nlm.nih.gov/37388230/
5. de Lange, Katrina M, Moutsianas, Loukas, Lee, James C, Anderson, Carl A, Barrett, Jeffrey C. 2017. Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. In Nature genetics, 49, 256-261. doi:10.1038/ng.3760. https://pubmed.ncbi.nlm.nih.gov/28067908/
6. Lin, Fengjie, Yang, Hanxuan, Huang, Zongwei, Ye, Yunbin, Qiu, Sufang. 2024. Magnesium-related gene ITGAL: a key immunotherapy predictor and prognostic biomarker in pan-cancer. In Frontiers in pharmacology, 15, 1464830. doi:10.3389/fphar.2024.1464830. https://pubmed.ncbi.nlm.nih.gov/39605903/
7. Xiao, Zengtuan, Nian, Zhe, Zhang, Mengzhe, Liu, Zhe, Zhang, Zhenfa. . Integrated analysis highlights the significance role of ITGAL in lung adenocarcinoma. In Journal of cellular and molecular medicine, 28, e18289. doi:10.1111/jcmm.18289. https://pubmed.ncbi.nlm.nih.gov/38613346/
8. Wang, Qiang, Xiao, GuangJun, Li, Na, Jiang, Xiulin, Li, Chunhong. 2023. lncRNA PCBP1-AS1 mediated downregulation of ITGAL as a prognostic biomarker in lung adenocarcinoma. In Aging, 15, 4510-4523. doi:10.18632/aging.204756. https://pubmed.ncbi.nlm.nih.gov/37256932/
9. De Andrade Costa, Amanda, Chatterjee, Jit, Cobb, Olivia, Dahiya, Sonika, Gutmann, David H. . RNA sequence analysis reveals ITGAL/CD11A as a stromal regulator of murine low-grade glioma growth. In Neuro-oncology, 24, 14-26. doi:10.1093/neuonc/noab130. https://pubmed.ncbi.nlm.nih.gov/34043012/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
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