Itgam-flox Mouse
Common Name
Itgam-flox
제품 ID
S-CKO-03158
Backgroud
C57BL/6JCya
품종 계통계통 ID
CKOCMP-16409-Itgam-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Itgam-flox Mouse (카탈로그 번호 S-CKO-03158)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Itgam-flox
품종 계통계통 ID
CKOCMP-16409-Itgam-B6J-VA
유전자명
제품 ID
S-CKO-03158
유전자 별칭
CD11b/CD18, CR3, CR3A, Cd11b, F730045J24Rik, Ly-40, MAC1, Mac-1, Mac-1a
배경
C57BL/6JCya
NCBI ID
변형 내용
Conditional knockout
염색체
Chr 7
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000064821
NCBI 전사체 ID
NM_001082960
타겟 영역
Exon 3
유효 영역 크기
~1.8 kb
유전자 연구 개요
Itgam, also known as Integrin subunit alpha M, encodes the CD11b chain of the Mac-1 integrin. Mac-1 integrin is involved in mediating cell adhesion of monocytes, macrophages, and granulocytes, as well as promoting phagocytosis of complement-coated particles. It is associated with immune and inflammatory response-related pathways and is of great biological importance in maintaining normal immune function [7].
In ischemic stroke, Itgam was identified as a critical gene. Quantitative assessment showed significant overexpression in patients. Its modulation influenced the secretion of inflammatory cytokines like IL-1β, IL-6, and TNF-α, and had an impact on neuronal apoptosis, suggesting it may be a potential therapeutic target [1].
In systemic lupus erythematosus (SLE), multiple meta-analyses demonstrated a significant association between ITGAM gene polymorphism (such as rs1143679) and SLE in multiple ethnic populations. The risk allele was related to increased serum calcification propensity in SLE patients, indicating an increased cardiovascular risk [2,5,6].
In neutrophilic asthma, Itgam was identified as a critical target to distinguish it from healthy/non-NA individuals, with a strong correlation between Itgam and macrophages [3].
In diabetic nephropathy and atherosclerosis, Itgam was found to be a key gene involved in basement membrane alterations, mainly expressed within macrophages, and therapeutic strategies targeting Itgam may mitigate basement membrane lesions [4].
In Kawasaki disease, NFIL3 aggravated human coronary artery endothelial cell injury by promoting Itgam transcription [8].
In conclusion, Itgam plays essential roles in immune and inflammatory responses. Model-based research, especially studies related to gene polymorphisms, has revealed its significance in diseases such as ischemic stroke, SLE, neutrophilic asthma, diabetic nephropathy, atherosclerosis, and Kawasaki disease. Understanding Itgam's functions provides potential directions for developing therapeutic strategies for these diseases.
References：
1. Hou, Lei, Li, Zhongchen, Guo, Xiaoli, Zhang, Liyong, Li, Zefu. 2024. ITGAM is a critical gene in ischemic stroke. In Aging, 16, 6852-6867. doi:10.18632/aging.205729. https://pubmed.ncbi.nlm.nih.gov/38637126/
2. Fan, Y, Li, L-H, Pan, H-F, Sun, Z-Q, Ye, D-Q. . Association of ITGAM polymorphism with systemic lupus erythematosus: a meta-analysis. In Journal of the European Academy of Dermatology and Venereology : JEADV, 25, 271-5. doi:10.1111/j.1468-3083.2010.03776.x. https://pubmed.ncbi.nlm.nih.gov/20629846/
3. Yan, Qian, Liu, Zixing, Chen, Yujing, Zhan, Shaofeng, Huang, Xiufang. 2023. ITGAM-macrophage modulation as a potential strategy for treating neutrophilic Asthma: insights from bioinformatics analysis and in vivo experiments. In Apoptosis : an international journal on programmed cell death, 29, 393-411. doi:10.1007/s10495-023-01914-5. https://pubmed.ncbi.nlm.nih.gov/37950848/
4. Lou, Yude, Li, Peng Hui, Liu, Xiao Qi, Chen, Chen Chen, Ma, Kun Ling. 2024. ITGAM-mediated macrophages contribute to basement membrane damage in diabetic nephropathy and atherosclerosis. In BMC nephrology, 25, 72. doi:10.1186/s12882-024-03505-1. https://pubmed.ncbi.nlm.nih.gov/38413872/
5. Halfon, Matthieu, Zhang, Li, Ehirchiou, Driss, Ribi, Camillo, Busso, Nathalie. 2023. ITGAM rs1143679 Variant in Systemic Lupus Erythematosus Is Associated with Increased Serum Calcification Propensity. In Genes, 14, . doi:10.3390/genes14051105. https://pubmed.ncbi.nlm.nih.gov/37239465/
6. Lee, Young Ho, Bae, Sang-Cheol. 2014. Association between the functional ITGAM rs1143679 G/A polymorphism and systemic lupus erythematosus/lupus nephritis or rheumatoid arthritis: an update meta-analysis. In Rheumatology international, 35, 815-23. doi:10.1007/s00296-014-3156-2. https://pubmed.ncbi.nlm.nih.gov/25315704/
7. Fagerholm, S C, MacPherson, M, James, M J, Sevier-Guy, C, Lau, C S. . The CD11b-integrin (ITGAM) and systemic lupus erythematosus. In Lupus, 22, 657-63. doi:10.1177/0961203313491851. https://pubmed.ncbi.nlm.nih.gov/23753600/
8. Chen, Li, Shangguan, Zhiyang, Dong, Zeya, Ding, Yunyun, Yang, Shulong. 2023. NFIL3 aggravates human coronary artery endothelial cell injury by promoting ITGAM transcription in Kawasaki disease. In Hematology (Amsterdam, Netherlands), 28, 2277502. doi:10.1080/16078454.2023.2277502. https://pubmed.ncbi.nlm.nih.gov/37933872/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
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