Lepr-flox Mouse
Common Name
Lepr-flox
제품 ID
S-CKO-03378
Backgroud
C57BL/6JCya
품종 계통계통 ID
CKOCMP-16847-Lepr-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Lepr-flox Mouse (카탈로그 번호 S-CKO-03378)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Lepr-flox
품종 계통계통 ID
CKOCMP-16847-Lepr-B6J-VA
유전자명
제품 ID
S-CKO-03378
유전자 별칭
db, Obr, obl, Leprb, Modb1, LEPROT, OB-RGRP, diabetes, obese-like
배경
C57BL/6JCya
NCBI ID
변형 내용
Conditional knockout
염색체
Chr 4
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000106921
NCBI 전사체 ID
NM_001122899
타겟 영역
Exon 3~4
유효 영역 크기
~3.5 kb
유전자 연구 개요
Lepr, short for leptin receptor, is a key component in the leptin signaling pathway. Leptin, a hormone protein, regulates food intake and energy expenditure, and Lepr is essential for leptin to exert its functions, thus playing a vital role in maintaining energy homeostasis [8].
A meta-analysis including 16 individual studies with 7827 subjects suggested that LEPR Gln223Arg polymorphism may not affect the susceptibility to type 2 diabetes (T2DM) [1]. Another meta-analysis showed that rs1137101 (p.R223Q) in LEPR was significantly associated with T2DM in all genetic models, while rs1137100 (p.R109K) and rs8179183 (p.K656N) were not significantly associated with T2DM [8].
In the context of cancer, a meta-analysis of 5819 cases and 8068 controls found that the LEPR K109R (rs1137100) genetic polymorphism did not significantly affect the overall cancer risk, but was associated with breast, lung, and gastric cancers in specific genetic models [4]. LEPR hypomethylation was significantly associated with gastric cancer in males, and it might also have the potential to predict recurrence in GC patients [2]. For colorectal cancer in the Mexican population, the c.326A>G heterozygous genotype of LEPR revealed an increased risk, while the AG haplotype had a protective effect [5].
In Chinese Mulao people, rs1137100, rs2767485, and rs465555 of LEPR were associated with osteoporosis [6]. In the Ukrainian population, the presence of the LEPR gene (rs1137101) polymorphism indicates an increased risk of the metabolic syndrome development [7]. Monoallelic pathogenic LEPR variants were functionally tested and do not elevate the risk of obesity or BMI levels [3].
In conclusion, Lepr is crucial for energy homeostasis regulation. Studies on Lepr gene polymorphisms and methylation have revealed its associations with various diseases such as T2DM, different types of cancers, osteoporosis, and metabolic syndrome. Functional studies of Lepr, especially those on its gene polymorphisms, contribute to understanding the genetic basis of these diseases and may provide potential targets for disease prevention and treatment.
References：
1. Liu, Ying, Chen, Shu-Qin, Jing, Zhao-Hai, Wang, Robin, Wang, Yan-Gang. 2015. Association of LEPR Gln223Arg polymorphism with T2DM: A meta-analysis. In Diabetes research and clinical practice, 109, e21-6. doi:10.1016/j.diabres.2015.05.042. https://pubmed.ncbi.nlm.nih.gov/26094585/
2. Yu, Hang, Pan, Ranran, Qi, Yuanling, Xu, Mingqing, Duan, Shiwei. 2020. LEPR hypomethylation is significantly associated with gastric cancer in males. In Experimental and molecular pathology, 116, 104493. doi:10.1016/j.yexmp.2020.104493. https://pubmed.ncbi.nlm.nih.gov/32659237/
3. Delplanque, Jérôme, Le Collen, Lauriane, Loiselle, Hélène, Froguel, Philippe, Bonnefond, Amélie. 2024. Monoallelic pathogenic variants in LEPR do not cause obesity. In American journal of human genetics, 111, 2668-2674. doi:10.1016/j.ajhg.2024.10.014. https://pubmed.ncbi.nlm.nih.gov/39561769/
4. Shi, Hui, Shu, Hexi, Huang, Changjia, Yang, Yong, Liu, Pengcheng. . Association of LEPR K109R polymorphisms with cancer risk: a systematic review and pooled analysis. In Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 19, 847-54. doi:. https://pubmed.ncbi.nlm.nih.gov/25261678/
5. Partida, Miriam, Gutiérrez, Melva, Ayala, María de la Luz, Alvizo, Carlos Rogelio, Peregrina, Jorge. 2019. LEPR polymorphisms and haplotypes in Mexican patients with colorectal cancer. In Biomedica : revista del Instituto Nacional de Salud, 39, 205-211. doi:10.7705/biomedica.v39i1.4091. https://pubmed.ncbi.nlm.nih.gov/31021558/
6. Ye, Guangbin, Huang, Yandong, Yin, Lianfei, Huang, Xiufeng, Bin, Xiaoyun. . Association between LEPR polymorphism and susceptibility of osteoporosis in Chinese Mulao people. In Artificial cells, nanomedicine, and biotechnology, 50, 10-16. doi:10.1080/21691401.2021.2020279. https://pubmed.ncbi.nlm.nih.gov/35086395/
7. Prodan, Andrii, Dzubanovsky, Ihor, Kamyshnyi, Oleksandr, Pidruchna, Svitlana, Voloshyn, Stanislava. 2023. GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population. In Endocrine regulations, 57, 269-278. doi:10.2478/enr-2023-0030. https://pubmed.ncbi.nlm.nih.gov/38127688/
8. Yang, Ming Ming, Wang, Jun, Fan, Jiao Jie, Teng, Yan, Li, Yan-Bo. 2016. Variations in the Obesity Gene "LEPR" Contribute to Risk of Type 2 Diabetes Mellitus: Evidence from a Meta-Analysis. In Journal of diabetes research, 2016, 5412084. doi:10.1155/2016/5412084. https://pubmed.ncbi.nlm.nih.gov/27195302/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
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