Ly75-flox Mouse
Common Name
Ly75-flox
제품 ID
S-CKO-03509
Backgroud
C57BL/6JCya
품종 계통계통 ID
CKOCMP-17076-Ly75-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Ly75-flox Mouse (카탈로그 번호 S-CKO-03509)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Ly75-flox
품종 계통계통 ID
CKOCMP-17076-Ly75-B6J-VA
유전자명
제품 ID
S-CKO-03509
유전자 별칭
CD205, DEC205, DEC-205
배경
C57BL/6JCya
NCBI ID
변형 내용
Conditional knockout
염색체
Chr 2
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000028362
NCBI 전사체 ID
NM_013825
타겟 영역
Exon 8
유효 영역 크기
~1.3 kb
유전자 연구 개요
Ly75, also known as DEC-205 or CD205, is an antigen receptor and endocytic receptor. It is expressed in immune cells, cancers, and mitotic germ cells in fish. In the immune system, it is involved in antigen processing and presentation [5,6]. In addition, it may play a role in pathways such as the Wnt/β -catenin pathway [1,2]. Ly75 has been associated with various biological processes and diseases, making it an important gene for study.
In epithelial ovarian cancer (EOC) cell lines, LY75 suppression can lead to mesenchymal-epithelial transition (MET), accompanied by reduced migratory and invasive capacity in vitro and enhanced tumor cell colonization and metastatic growth in vivo [1,2,6]. In skin cutaneous melanoma, Ly75 mRNA expression is lower in cancer tissues, and its expression is positively correlated with natural killer (NK) cell infiltration and good patient survival [3]. In mice, Ly75 has been identified as a quantitative trait gene for resistance to obesity [4]. Also, in bladder cancer, nitidine chloride can inhibit cell proliferation, migration, and invasion by down-regulating LY75 [7].
In conclusion, Ly75 is involved in multiple biological processes and diseases. Its role in cancer metastasis, immune cell infiltration, and obesity resistance has been revealed through in vivo and in vitro studies. These findings contribute to understanding the underlying mechanisms of these diseases and may provide potential targets for treatment.
References：
1. Mehdi, Sadia, Bachvarova, Magdalena, Scott-Boyer, Marie-Pier, Droit, Arnaud, Bachvarov, Dimcho. 2020. LY75 Ablation Mediates Mesenchymal-Epithelial Transition (MET) in Epithelial Ovarian Cancer (EOC) Cells Associated with DNA Methylation Alterations and Suppression of the Wnt/β-Catenin Pathway. In International journal of molecular sciences, 21, . doi:10.3390/ijms21051848. https://pubmed.ncbi.nlm.nih.gov/32156068/
2. Mehdi, Sadia, Macdonald, Elizabeth, Galpin, Kristianne, Vanderhyden, Barbara, Bachvarov, Dimcho. 2020. LY75 Suppression in Mesenchymal Epithelial Ovarian Cancer Cells Generates a Stable Hybrid EOC Cellular Phenotype, Associated with Enhanced Tumor Initiation, Spreading and Resistance to Treatment in Orthotopic Xenograft Mouse Model. In International journal of molecular sciences, 21, . doi:10.3390/ijms21144992. https://pubmed.ncbi.nlm.nih.gov/32679765/
3. Gil, Minchan, Kim, Kyung Eun. 2020. Systematic Multiomic Analysis of Ly75 Gene Expression and Its Prognostic Value Through the Infiltration of Natural Killer (NK) Cells in Skin Cutaneous Melanoma. In Journal of clinical medicine, 9, . doi:10.3390/jcm9051383. https://pubmed.ncbi.nlm.nih.gov/32397120/
4. Makino, Keita, Ishikawa, Akira. 2018. Genetic identification of Ly75 as a novel quantitative trait gene for resistance to obesity in mice. In Scientific reports, 8, 17658. doi:10.1038/s41598-018-36073-0. https://pubmed.ncbi.nlm.nih.gov/30518881/
5. Nagasawa, Kazue, Shikina, Shinya, Takeuchi, Yutaka, Yoshizaki, Goro. 2010. Lymphocyte antigen 75 (Ly75/CD205) is a surface marker on mitotic germ cells in rainbow trout. In Biology of reproduction, 83, 597-606. doi:10.1095/biolreprod.109.082081. https://pubmed.ncbi.nlm.nih.gov/20554922/
6. Faddaoui, Adnen, Bachvarova, Magdalena, Plante, Marie, Vanderhyden, Barbara, Bachvarov, Dimcho. . The mannose receptor LY75 (DEC205/CD205) modulates cellular phenotype and metastatic potential of ovarian cancer cells. In Oncotarget, 7, 14125-42. doi:10.18632/oncotarget.7288. https://pubmed.ncbi.nlm.nih.gov/26871602/
7. Wang, Shi-Shuo, Zhai, Gao-Qiang, Huang, Zhi-Guang, Cheng, Ji-Wen, Chen, Gang. 2023. Nitidine chloride regulates cell function of bladder cancer in vitro through downregulating Lymphocyte antigen 75. In Naunyn-Schmiedeberg's archives of pharmacology, 396, 2071-2085. doi:10.1007/s00210-023-02446-0. https://pubmed.ncbi.nlm.nih.gov/36914902/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
Cyagen문의하기
맞춤형 동물 모델 관련 상담을 위해 Cyagen 전문가와 연락해 보세요. 아래 양식을 작성하여 상담을 시작하거나 견적을 요청하시기 바랍니다.
Cyagen은 고객님의 개인정보를 소중히 여깁니다. 최신 제품, 서비스 및 인사이트를 안내드리고자 합니다. 고객님의 수신 설정은 다음과 같습니다:
해당 커뮤니케이션은 언제든지 수신 거부하실 수 있습니다. 수신 거부 방법 및 데이터 보호에 대한 자세한 내용은 개인정보처리방침을 참고해 주시기 바랍니다.
아래 버튼을 클릭함으로써, 요청하신 콘텐츠 제공을 위해 본 양식을 통해 제출된 개인정보를 Cyagen이 저장 및 처리하는 데 동의하게 됩니다.