Serpine1-flox Mouse

Serpine1, also known as Plasminogen Activator Inhibitor (PAI-1), is a key member of the serine proteinase inhibitor E superfamily. It plays a crucial role in the fibrinolytic system and is involved in various biological processes. It has been associated with multiple signaling pathways such as the NF-κB signaling pathway, which is relevant in many disease-related processes [1,2].

In colorectal cancer, therapy-induced senescent tumor cells release extracellular vesicles enriched in SERPINE1, which promote cancer progression. SERPINE1 binds to p65, promoting its nuclear translocation and activating the NF-κB signaling pathway [1]. In gastric cancer, SERPINE1 is up-regulated, related to poor prognosis, and may regulate cuproptosis and the immune microenvironment. It is negatively correlated with cuproptosis-related genes FDX1, LIAS, LIPT1, and PDHA1, and positively correlated with APOE. It may also promote an inhibitory immune microenvironment [3].

In conclusion, Serpine1 is an important gene involved in the fibrinolytic system and is associated with multiple diseases, especially cancers. Studies in cancer models have revealed its role in promoting tumor progression, regulating the immune microenvironment, and being a potential prognostic biomarker and therapeutic target [1,3].