Ppp1r17-flox Mouse

Ppp1r17, the protein phosphatase 1 regulatory subunit 17, is involved in multiple biological processes. It has been associated with the regulation of synaptic function, with its phosphorylation and nuclear-cytoplasmic translocation affecting gene expression in this regard [1]. It may also be related to neural progenitor cell cycle progression as it has been shown to slow down this process, paralleling changes seen in primate and human neurodevelopment [3].

In mice, DMH-specific Prkg1 knockdown, which suppresses age-associated Ppp1r17 translocation, and the chemogenetic activation of DMHPpp1r17 neurons significantly ameliorate age-associated dysfunction in white adipose tissue (WAT), increase physical activity, and extend lifespan. This indicates that DMHPpp1r17 neurons marked by Ppp1r17 expression regulate aging and longevity in mice through hypothalamic-adipose inter-tissue communication [1]. Also, in ob/ob mice, chemogenetic activation of PPP1R17 neurons decreased food intake and body weight, while inhibition increased them, suggesting that these neurons function to restrict food intake to limit overconsumption [2].

In conclusion, Ppp1r17 plays a crucial role in regulating aging, lifespan, and food intake in mice. The studies using mouse models have revealed its significance in hypothalamic-adipose inter-tissue communication and the control of food intake, providing insights into potential mechanisms related to age-associated diseases and metabolic disorders.