Pvt1-flox Mouse

Pvt1, also known as plasmacytoma variant translocation 1, is a long non-coding RNA. It has oncogenic properties and is involved in regulating the proliferation and growth of many cancers. Pvt1 exerts its functions, in part, through microRNAs (miRNAs), and is associated with several cancer-related pathways such as TGF-β, Wnt/β-catenin, PI3K/AKT, and mTOR pathways [1,4].

In pancreatic cancer, gain-and loss-of-function assays in vitro and in vivo showed that Pvt1 impairs the sensitivity to gemcitabine by up-regulating Pygo2 and ATG14 through sponging miR-619-5p, thus regulating Wnt/β-catenin signaling and autophagic activity [2].

In liver cancer, depletion of lncPvt1 accelerated ferroptosis of liver cancer cells, and ketamine-induced cell growth suppression and ferroptosis were related to the regulation of the lncPvt1/miR-214-3p/GPX4 axis [3].

In gastric cancer, depletion of Pvt1 promoted the expression of miR-16 and suppressed CCND1 expression, inhibiting the viability, invasion and cell cycle progression of GC cells [5].

In conclusion, Pvt1 plays a crucial role in cancer progression, especially in pancreatic, liver and gastric cancers. Loss-of-function experiments in these cancer models have revealed its oncogenic role, mainly through miRNA-mediated mechanisms and regulation of related signaling pathways, providing potential therapeutic targets for cancer treatment.