Ism2-flox Mouse

Isthmin 2 (ISM2) is a protein-coding gene. The Isthmin family, including ISM2, contains a TSR1 domain followed by an AMOP domain and is involved in diverse developmental and physiological processes [1].

A study found that ISM2 protein was decreased in patients with preeclampsia compared to the control group, suggesting its potential involvement in the pathogenesis of preeclampsia, and was overexpressed in choriocarcinoma, indicating a possible role in cancer angiogenesis [2]. Another study showed that low ISM2 expression was associated with a less advanced clinical stage and better survival outcomes in HPV-infected colorectal cancer, correlating with a strong tumor immune response [3]. Additionally, ISM2 was identified as one of the autoantibody-targeting genes in the discovery phase of developing a diagnostic tool for early esophageal squamous cell carcinoma [4].

In conclusion, ISM2 appears to play roles in angiogenesis-related processes such as in preeclampsia and choriocarcinoma, and is associated with the prognosis in HPV-infected colorectal cancer. Its involvement in autoantibody-related early esophageal squamous cell carcinoma diagnosis also shows its potential significance in disease diagnosis and pathophysiological processes.