Tex9-flox Mouse

Tex9, or Testis-expressed protein 9, is a gene with diverse functions. It has been associated with cilia-related processes as its cilia/basal body localization was experimentally confirmed, and it may be involved in ciliogenesis/flagellum formation in germ cells [3,5].

In esophageal squamous cell carcinoma (ESCC), TEX9 expression was found to be positively associated with eIF3b expression and positively correlated with TNM stage. TEX9 and eIF3b functionally synergize to promote the proliferation and migration, and inhibit the apoptosis of ESCC cells through the activation of AKT signaling pathway [1].

In a Drosophila model, the knockdown of TEX9 resulted in normal fertility, indicating that TEX9 may not be essential for male fertility in this model [2].

In a syngeneic triple-negative breast cancer (TNBC) model, Tex9 was identified as one of the genes that selectively regulated adaptive anti-tumor immunity, demonstrating its impact on anti-tumor immunity [4].

In conclusion, Tex9 has functions in ciliary processes, cancer progression, and anti-tumor immunity. The studies in different models, such as Drosophila and mouse models, have provided insights into its role in specific biological processes and disease conditions, highlighting its importance in understanding ciliary-related functions and cancer-related mechanisms.