Tnfsf9-flox Mouse
Common Name
Tnfsf9-flox
제품 ID
S-CKO-06398
Backgroud
C57BL/6JCya
품종 계통계통 ID
CKOCMP-21950-Tnfsf9-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Tnfsf9-flox Mouse (카탈로그 번호 S-CKO-06398)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Tnfsf9-flox
품종 계통계통 ID
CKOCMP-21950-Tnfsf9-B6J-VA
유전자명
제품 ID
S-CKO-06398
유전자 별칭
Ly63l, 4-1BBL, Cd137l, 4-1BB-L
배경
C57BL/6JCya
NCBI ID
변형 내용
Conditional knockout
염색체
Chr 17
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000039490
NCBI 전사체 ID
NM_009404
타겟 영역
Exon 3
유효 영역 크기
~1.7 kb
유전자 연구 개요
Tnfsf9, also known as CD137L/4-1BBL, is a member of the tumor necrosis factor superfamily. It functions as a T-cell co-stimulator, playing a role in cancer immunotherapy and being involved in regulating immune cell functions. It has implications in various biological processes related to the immune response and cancer [1,7].
In pancreatic cancer, Tnfsf9 expression is elevated and is associated with poor prognosis. It can promote pancreatic cancer metastasis by inducing M2 macrophage polarization through Src/FAK/p-Akt/IL-1β signaling [3], as well as through Wnt/Snail signaling [4].
In glioma, hypoxia can upregulate Tnfsf9 expression in a histone-lactylation-dependent manner, leading to M2 macrophage polarization and promoting glioma progression [2].
In hepatocellular carcinoma, Tnfsf9 expression is downregulated, and overexpression or treatment with its recombinant protein can inhibit HCC cell proliferation, migration, and invasion both in vitro and in vivo, suggesting it may be a tumor suppressor [7].
In patients with metastatic renal cell carcinoma treated with nivolumab and ipilimumab, Tnfsf9 expression may predict treatment response, with high-expression tumors showing an activated adaptive immune response [5].
Inherited Tnfsf9 deficiency in a patient led to broad Epstein-Barr virus infection with EBV+ smooth muscle tumors, highlighting the role of the CD137-CD137L (Tnfsf9) pathway in anti-EBV immunity [6].
In conclusion, Tnfsf9 has diverse functions in the immune response and cancer. Its role in promoting or inhibiting tumor progression varies depending on the cancer type. Studies on Tnfsf9, including those using relevant models, have provided insights into its functions in diseases such as cancer and viral infections, which may help develop new therapeutic strategies.
References：
1. Wu, Jiao, Wang, Yunpeng. 2022. Role of TNFSF9 bidirectional signal transduction in antitumor immunotherapy. In European journal of pharmacology, 928, 175097. doi:10.1016/j.ejphar.2022.175097. https://pubmed.ncbi.nlm.nih.gov/35714694/
2. Li, Min, Sun, Pingfeng, Tu, Binfeng, Li, Donghai, He, Wei. 2024. Hypoxia conduces the glioma progression by inducing M2 macrophage polarization via elevating TNFSF9 level in a histone-lactylation-dependent manner. In American journal of physiology. Cell physiology, 327, C487-C504. doi:10.1152/ajpcell.00124.2024. https://pubmed.ncbi.nlm.nih.gov/39010835/
3. Wu, Jiao, Wang, Yunpeng, Yang, Yichun, Jiang, Zhongxiang, Jiang, Zheng. 2021. TNFSF9 promotes metastasis of pancreatic cancer by regulating M2 polarization of macrophages through Src/FAK/p-Akt/IL-1β signaling. In International immunopharmacology, 102, 108429. doi:10.1016/j.intimp.2021.108429. https://pubmed.ncbi.nlm.nih.gov/34906856/
4. Wu, Jiao, Wang, Yunpeng, Yang, Yichun, Jiang, Zhongxiang, Jiang, Zheng. 2021. TNFSF9 promotes metastasis of pancreatic cancer through Wnt/Snail signaling and M2 polarization of macrophages. In Aging, 13, 21571-21586. doi:10.18632/aging.203497. https://pubmed.ncbi.nlm.nih.gov/34517345/
5. Isoda, Bunpei, Kandori, Shuya, Sazuka, Tomokazu, Ichikawa, Tomohiko, Nishiyama, Hiroyuki. 2024. TNFSF9 Is Associated with Favorable Tumor Immune Microenvironment in Patients with Renal Cell Carcinoma Who Are Treated with the Combination Therapy of Nivolumab and Ipilimumab. In International journal of molecular sciences, 25, . doi:10.3390/ijms25137444. https://pubmed.ncbi.nlm.nih.gov/39000552/
6. Fournier, Benjamin, Hoshino, Akihiro, Bruneau, Julie, Neven, Bénédicte, Latour, Sylvain. 2022. Inherited TNFSF9 deficiency causes broad Epstein-Barr virus infection with EBV+ smooth muscle tumors. In The Journal of experimental medicine, 219, . doi:10.1084/jem.20211682. https://pubmed.ncbi.nlm.nih.gov/35657354/
7. Shen, Yu Ling, Gan, Yu, Gao, Hai Feng, Wang, Jia Dong, Tu, Hong. . TNFSF9 exerts an inhibitory effect on hepatocellular carcinoma. In Journal of digestive diseases, 18, 395-403. doi:10.1111/1751-2980.12489. https://pubmed.ncbi.nlm.nih.gov/28547807/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
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