Lpin3-flox Mouse
Common Name
Lpin3-flox
제품 ID
S-CKO-12788
Backgroud
C57BL/6JCya
품종 계통계통 ID
CKOCMP-64899-Lpin3-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Lpin3-flox Mouse (카탈로그 번호 S-CKO-12788)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Lpin3-flox
품종 계통계통 ID
CKOCMP-64899-Lpin3-B6J-VA
유전자명
제품 ID
S-CKO-12788
유전자 별칭
mKIAA4023, 9130206L11Rik
배경
C57BL/6JCya
NCBI ID
변형 내용
Conditional knockout
염색체
Chr 2
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000040872
NCBI 전사체 ID
NM_001199118
타겟 영역
Exon 4~7
유효 영역 크기
~2.7 kb
유전자 연구 개요
Lpin3, encoding phosphatidate phosphatase type 1 enzyme, is involved in lipid metabolism, playing a role in the de novo biosynthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine [6]. It has been associated with various biological processes and diseases, and genetic models are valuable for studying its functions.
In colorectal cancer, LPIN3 is highly expressed and promotes tumor growth. LPIN3 knockdown in vivo strengthened CD8+ T cell-mediated cytotoxicity, infiltration and activation, indicating that LPIN3 may drive CRC progression by regulating β-catenin signaling and CD8+ T cell activity [1].
In a male infant, an LPIN3 mutation was associated with failure to thrive [2].
In liver transplantation, LPIN3 was among the key proteins differentially expressed between early allograft dysfunction (EAD) and non-EAD groups, with potential implications for assessing graft quality and predicting EAD [3].
In Chinese fat-tailed sheep, Lpin3 mRNA was prominently expressed in liver and small intestine, and its expression was associated with slaughter and tail traits [4]. A novel cell-penetrating peptide was identified from human LPIN3, which could potentially be used in drug delivery systems [5].
In conclusion, Lpin3 plays essential roles in lipid metabolism, and its dysregulation is associated with diseases like colorectal cancer and growth disorders. Studies, including those using in vivo models, have provided insights into its functions in specific biological processes and disease conditions, contributing to our understanding of related disease mechanisms.
References：
1. Zhang, Xiaoming, Fang, Hao, Wu, Wenliang, Wang, Haizhou, Shi, Yifei. 2025. LPIN3 promotes colorectal cancer growth by dampening intratumoral CD8+ T cell effector function. In Cancer immunology, immunotherapy : CII, 74, 135. doi:10.1007/s00262-025-03989-2. https://pubmed.ncbi.nlm.nih.gov/40042548/
2. Altay, Derya, Gorukmez, Orhan, Arslan, Duran. 2020. Coexistence of Three Different Mutations in a Male Infant: neurofibromatosis Type 1, Progressive Familial Intrahepatic Cholestasis Type 2 and LPIN3. In Fetal and pediatric pathology, 41, 293-298. doi:10.1080/15513815.2020.1783405. https://pubmed.ncbi.nlm.nih.gov/32597698/
3. Lin, Yimou, Huang, Haitao, Cao, Jiaying, Zheng, Shusen, Ling, Qi. 2024. An integrated proteomics and metabolomics approach to assess graft quality and predict early allograft dysfunction after liver transplantation: a retrospective cohort study. In International journal of surgery (London, England), 110, 3480-3494. doi:10.1097/JS9.0000000000001292. https://pubmed.ncbi.nlm.nih.gov/38502860/
4. Jiao, Xiao-Li, Jing, Jiong-Jie, Qiao, Li-Ying, Jia, Xia-Li, Liu, Wen-Zhong. 2016. Ontogenetic Expression of Lpin2 and Lpin3 Genes and Their Associations with Traits in Two Breeds of Chinese Fat-tailed Sheep. In Asian-Australasian journal of animal sciences, 29, 333-42. doi:10.5713/ajas.15.0467. https://pubmed.ncbi.nlm.nih.gov/26950863/
5. Lim, Sangho, Kim, Won-ju, Kim, Yeon-ho, Choi, Je-Min. 2012. Identification of a novel cell-penetrating peptide from human phosphatidate phosphatase LPIN3. In Molecules and cells, 34, 577-82. doi:10.1007/s10059-012-0284-y. https://pubmed.ncbi.nlm.nih.gov/23263658/
6. He, Xiaoping, Xu, Xuewen, Liu, Bang. 2008. Molecular characterization, chromosomal localization and association analysis with back-fat thickness of porcine LPIN2 and LPIN3. In Molecular biology reports, 36, 1819-24. doi:10.1007/s11033-008-9385-2. https://pubmed.ncbi.nlm.nih.gov/18989753/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
Cyagen문의하기
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