Derl3-flox Mouse
Common Name
Derl3-flox
제품 ID
S-CKO-14802
Backgroud
C57BL/6JCya
품종 계통계통 ID
CKOCMP-70377-Derl3-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Derl3-flox Mouse (카탈로그 번호 S-CKO-14802)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Derl3-flox
품종 계통계통 ID
CKOCMP-70377-Derl3-B6J-VA
유전자명
제품 ID
S-CKO-14802
유전자 별칭
IZP6, derlin-3, 1810006I20Rik, 1810063P04Rik
배경
C57BL/6JCya
NCBI ID
변형 내용
Conditional knockout
염색체
Chr 10
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000009236
NCBI 전사체 ID
NM_024440
타겟 영역
Exon 1~7
유효 영역 크기
~2.6 kb
유전자 연구 개요
DERL3, also known as Derlin-3, is a key gene in the endoplasmic reticulum-associated protein degradation pathway. It is involved in the degradation of misfolded lumenal glycoproteins induced by endoplasmic reticulum (ER) stress [7].
DERL3 has been studied in multiple disease contexts. In colorectal cancer, its low expression in cancer tissues is linked to a high rate of lymphatic and distant metastasis. Overexpression of DERL3 in HT29 cells suppresses their proliferative, migratory, and invasive capacities, likely through negatively regulating MYCN level [1].
In gastric cancer, DERL3 acts as a tumor suppressor, with its promoter methylation correlated with tumor clinical features. Genes co-expressed with DERL3 are involved in adaptive immune response, T cell activation, etc. [3].
In nasopharyngeal carcinoma, Epstein-Barr virus latent membrane protein 1 represses DERL3 via DNA methylation, and DERL3 knockdown leads to increased cell proliferation, migration, and invasion [5].
In lung adenocarcinoma, DERL3 is upregulated in carcinoma tissues, and high-expressed patients have a worse response to chemotherapy and immunotherapy. It is positively correlated with B cell activation and unfolded protein response (UPR) [6].
In renal clear cell carcinoma, elevated DERL3 expression indicates a poor prognosis [4].
In rheumatoid arthritis, DERL3 is up-regulated in fibroblast-like synoviocytes of RA patients, and TNF-α-induced DERL3 expression promotes inflammation through activating the NF-κB signaling pathway [2].
In conclusion, DERL3 plays crucial roles in various biological processes and diseases. In cancer, it often acts as a tumor suppressor or is associated with prognosis. In rheumatoid arthritis, it contributes to inflammation. Studies on DERL3 help understand disease mechanisms and may provide potential therapeutic targets.
References：
1. Yu, Fubing, Mou, Bo, Sheng, Juan, Qin, Xiangxin, Yu, Jiaman. 2020. DERL3 suppresses colorectal cancer metastasis through negatively regulating MYCN level. In Minerva medica, 114, 316-322. doi:10.23736/S0026-4806.20.06657-4. https://pubmed.ncbi.nlm.nih.gov/32538588/
2. Geng, Manman, Xu, Ke, Meng, Liesu, Zhu, Wenhua, Lu, Shemin. 2020. Up-regulated DERL3 in fibroblast-like synoviocytes exacerbates inflammation of rheumatoid arthritis. In Clinical immunology (Orlando, Fla.), 220, 108579. doi:10.1016/j.clim.2020.108579. https://pubmed.ncbi.nlm.nih.gov/32866644/
3. Li, Yongyuan, Liu, Hongjie, Chen, Hekai, Cai, Xuejun, He, Xianghui. 2019. DERL3 functions as a tumor suppressor in gastric cancer. In Computational biology and chemistry, 84, 107172. doi:10.1016/j.compbiolchem.2019.107172. https://pubmed.ncbi.nlm.nih.gov/31862624/
4. Fan, Weining, Ran, Lingxiang, Wang, Lexin, Chi, Hao. 2024. The elevated DERL3 expression indicates poor prognosis in renal clear cell carcinoma. In Asian journal of surgery, , . doi:10.1016/j.asjsur.2024.06.115. https://pubmed.ncbi.nlm.nih.gov/39034257/
5. Kondo, Satoru, Okabe, Atsushi, Nakagawa, Takuya, Yoshizaki, Tomokazu, Kaneda, Atsushi. 2022. Repression of DERL3 via DNA methylation by Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma. In Biochimica et biophysica acta. Molecular basis of disease, 1869, 166598. doi:10.1016/j.bbadis.2022.166598. https://pubmed.ncbi.nlm.nih.gov/36372158/
6. Lin, Lanlan, Lin, Guofu, Lin, Hai, Xu, Yuan, Zeng, Yiming. 2022. Integrated profiling of endoplasmic reticulum stress-related DERL3 in the prognostic and immune features of lung adenocarcinoma. In Frontiers in immunology, 13, 906420. doi:10.3389/fimmu.2022.906420. https://pubmed.ncbi.nlm.nih.gov/36275646/
7. Lopez-Serra, Paula, Marcilla, Miguel, Villanueva, Alberto, Albar, Juan Pablo, Esteller, Manel. 2014. A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect. In Nature communications, 5, 3608. doi:10.1038/ncomms4608. https://pubmed.ncbi.nlm.nih.gov/24699711/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
Cyagen문의하기
맞춤형 동물 모델 관련 상담을 위해 Cyagen 전문가와 연락해 보세요. 아래 양식을 작성하여 상담을 시작하거나 견적을 요청하시기 바랍니다.
Cyagen은 고객님의 개인정보를 소중히 여깁니다. 최신 제품, 서비스 및 인사이트를 안내드리고자 합니다. 고객님의 수신 설정은 다음과 같습니다:
해당 커뮤니케이션은 언제든지 수신 거부하실 수 있습니다. 수신 거부 방법 및 데이터 보호에 대한 자세한 내용은 개인정보처리방침을 참고해 주시기 바랍니다.
아래 버튼을 클릭함으로써, 요청하신 콘텐츠 제공을 위해 본 양식을 통해 제출된 개인정보를 Cyagen이 저장 및 처리하는 데 동의하게 됩니다.