Tgfbrap1-flox Mouse
Common Name
Tgfbrap1-flox
제품 ID
S-CKO-15631
Backgroud
C57BL/6JCya
품종 계통계통 ID
CKOCMP-73122-Tgfbrap1-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Tgfbrap1-flox Mouse (카탈로그 번호 S-CKO-15631)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Tgfbrap1-flox
품종 계통계통 ID
CKOCMP-73122-Tgfbrap1-B6J-VA
유전자명
제품 ID
S-CKO-15631
유전자 별칭
Trap1, 3110018K12Rik
배경
C57BL/6JCya
NCBI ID
변형 내용
Conditional knockout
염색체
Chr 1
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000095014
NCBI 전사체 ID
NM_001013025
타겟 영역
Exon 5
유효 영역 크기
~1.2 kb
유전자 연구 개요
Tgfbrap1, also known as TGF-β receptor-associated binding protein 1, plays crucial roles in multiple biological processes. It is involved in the TGF-β signaling pathway, which regulates various cellular functions such as cell growth, differentiation, apoptosis, and extracellular matrix production. Dysregulation of this pathway can lead to numerous diseases [1,5,7].
In pulmonary fibrosis, Chitinase 1 (CHIT1) enhances TGF-β1-stimulated fibrotic responses through inhibiting TGF-β1 induction of SMAD7. This effect is mediated by CHIT1's interaction with Tgfbrap1, highlighting Tgfbrap1's role in the pathogenesis of pulmonary fibrosis [1,7].
In goose follicular granulosa cells, knockdown of Tgfbrap1 mRNA level reduces apoptosis rate and enhances the secretion of E2 and P4, indicating its role in regulating follicular development [2].
Also, a variant at Tgfbrap1 (rs2241797) is significantly associated with type 2 diabetes mellitus and affects diabetes-related miRNA expression [3].
Additionally, the A variant of rs17687727 in Tgfbrap1 influences the susceptibility to antituberculosis drug-induced liver injury in the Han Chinese population [4].
In liver cancer, Tgfbrap1 stabilizes TGF-β receptor type 1 (TGFBR1), potentiating TGF-β signaling and promoting liver cancer stemness and drug resistance [5].
Piperine, which protects against acetaminophen-induced hepatotoxicity, may mediate its effects through regulating Tgfbrap1 [6].
Overexpression of Tgfbrap1, a CORVET-specific subunit, decreases the amount of assembled HOPS complex, affecting autophagosome-lysosome fusion and lysosomal hydrolase delivery [8].
In conclusion, Tgfbrap1 is essential in the TGF-β signaling pathway and is involved in various biological processes and disease conditions such as pulmonary fibrosis, follicular development, type 2 diabetes, antituberculosis drug-induced liver injury, liver cancer, hepatotoxicity response, and endosomal tethering complex regulation. The study of Tgfbrap1 through genetic models helps to understand its function in these diseases, potentially providing new insights for disease treatment and prevention.
References：
1. Lee, Chang-Min, He, Chuan-Hua, Park, Jin Wook, Elias, Jack A, Lee, Chun Geun. 2024. Retraction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3. In Life science alliance, 7, . doi:10.26508/lsa.202402987. https://pubmed.ncbi.nlm.nih.gov/39209538/
2. Wang, Zhixiu, Lu, Lu, Gu, Tiantian, Xu, Qi, Chen, Guohong. 2020. The effects of FAR1 and TGFBRAP1 on the proliferation and apoptosis of follicular granulosa cells in goose (Anser cygnoides). In Gene, 769, 145194. doi:10.1016/j.gene.2020.145194. https://pubmed.ncbi.nlm.nih.gov/33007376/
3. Yang, Song, Chen, Xiaotian, Yang, Mengyao, Liu, Chunlan, Shen, Chong. 2018. The variant at TGFBRAP1 is significantly associated with type 2 diabetes mellitus and affects diabetes-related miRNA expression. In Journal of cellular and molecular medicine, 23, 83-92. doi:10.1111/jcmm.13885. https://pubmed.ncbi.nlm.nih.gov/30461200/
4. Zhang, Jingwei, Zhao, Zhenzhen, Bai, Hao, Lyv, Mengyuan, Ying, Binwu. 2019. The Variant at TGFBRAP1 but Not TGFBR2 Is Associated with Antituberculosis Drug-Induced Liver Injury. In Evidence-based complementary and alternative medicine : eCAM, 2019, 1685128. doi:10.1155/2019/1685128. https://pubmed.ncbi.nlm.nih.gov/31534460/
5. Liu, Kewei, Tian, Fanxuan, Chen, Xu, Wang, Tao, Wang, Bin. 2024. Stabilization of TGF-β Receptor 1 by a Receptor-Associated Adaptor Dictates Feedback Activation of the TGF-β Signaling Pathway to Maintain Liver Cancer Stemness and Drug Resistance. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11, e2402327. doi:10.1002/advs.202402327. https://pubmed.ncbi.nlm.nih.gov/38981014/
6. Morsy, M A, Younis, N S, El-Sheikh, A A K, El-Daly, M, Mohafez, O M. . Protective mechanisms of piperine against acetaminophen-induced hepatotoxicity may be mediated through TGFBRAP1. In European review for medical and pharmacological sciences, 24, 10169-10180. doi:10.26355/eurrev_202010_23237. https://pubmed.ncbi.nlm.nih.gov/33090425/
7. Lee, Chang-Min, He, Chuan-Hua, Park, Jin Wook, Elias, Jack A, Lee, Chun Geun. 2019. Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3. In Life science alliance, 2, . doi:10.26508/lsa.201900350. https://pubmed.ncbi.nlm.nih.gov/31085559/
8. Sőth, Ármin, Molnár, Márton, Lőrincz, Péter, Simon-Vecsei, Zsófia, Juhász, Gábor. 2024. CORVET-specific subunit levels determine the balance between HOPS/CORVET endosomal tethering complexes. In Scientific reports, 14, 10146. doi:10.1038/s41598-024-59775-0. https://pubmed.ncbi.nlm.nih.gov/38698024/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
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