Mindy1-flox Mouse

MINDY1, a member of the motif interacting with Ub-containing novel DUB family, functions as a deubiquitylase. It is involved in multiple biological processes and associated with various signaling pathways, playing a significant role in maintaining normal cellular functions and disease-related processes. Genetic models, such as KO/CKO mouse models, can be valuable for studying its functions.

In breast cancer, MINDY1 interacts with estrogen receptor α (ERα), mediating ERα deubiquitination and increasing its stability, promoting breast cancer cell proliferation. High MINDY1 expression is associated with poor prognosis [1].

In bladder cancer, MINDY1 interacts with, deubiquitylates, and stabilizes YAP, promoting bladder cancer progression [2].

In liver cancer, MINDY1 is highly expressed in liver cancer stem cells. Knocking out MINDY1 reduces the expression of stem markers, self-renewal ability, and tumor growth, and its high expression is an independent risk factor for poor prognosis [3].

In conclusion, MINDY1 is crucial in regulating the stability of key proteins in multiple cancer-related signaling pathways. The study of MINDY1 using KO/CKO mouse models has provided insights into its role in breast, bladder, and liver cancers, offering potential therapeutic targets for these diseases.