Nkrf-flox Mouse

NKRF, also known as NF-κB-repressing factor, plays a significant role in the transcriptional inhibition of various specific genes and is involved in regulating the NF-κB signaling pathway [1,2,3,4,5,6,7]. The NF-κB signaling pathway is crucial in many biological processes such as inflammation, immune response, and cell survival.

In a CF-specific NKRF-knockout (NKRF-CKO) mouse model, NKRF-CKO mice demonstrated worse cardiac function, reduced survival, increased infarct size, heart weight, and MMP2 and MMP9 expression post-myocardial infarction compared with littermates. NKRF inhibits CF migration and invasion in vitro by down-regulating MMP2 and MMP9 expression. Mechanistically, NKRF inhibits human antigen R (HuR) transcription, decreasing HuR-targeted Mmp2 and Mmp9 mRNA stability [1].

In conclusion, NKRF is essential in the context of cardiac remodeling post-myocardial infarction, as revealed by the NKRF-CKO mouse model. It also has implications in other diseases such as Alzheimer's disease, atherosclerosis, and lung cancer, where it regulates the NF-κB signaling pathway [2,3,6]. Understanding NKRF's function provides potential therapeutic targets for these disease conditions.