Pus7l-flox Mouse

Pus7l, a gene related to pseudouridine synthases, is involved in RNA pseudouridine modification. Pseudouridine modification is an important RNA epigenetic modification that can affect RNA stability, function, and various biological processes [3,4].

In a study on sepsis, increased frequency of tryptic phosphopeptides from PUS7L was observed, and increases in mean precursor intensity of peptides from PUS7L were associated with sepsis, suggesting its potential role in the disease [1]. Additionally, rare-variant association analysis revealed that PUS7L has rare-variant associations with age-related hearing loss, indicating its possible involvement in this sensory deficit [2]. Also, in the research on protein-protein interactions, PUS7L was identified as a new interaction partner of AHCY [5]. The CNV of PUS7L was associated with prognosis in hepatocellular carcinoma [3]. In colorectal cancer, the Ψ levels correlated with the expression levels of PUS7L, suggesting its potential significance in the disease [4].

In conclusion, PUS7L is involved in RNA pseudouridine modification and plays roles in multiple diseases including sepsis, age-related hearing loss, hepatocellular carcinoma, and colorectal cancer. Studies on PUS7L contribute to understanding the mechanisms of these diseases and may offer new perspectives for diagnosis and treatment.