Nrgn-flox Mouse
Common Name
Nrgn-flox
제품 ID
S-CKO-18181
Backgroud
C57BL/6JCya
품종 계통계통 ID
CKOCMP-64011-Nrgn-B6J-VB
상태
이 마우스 계통을 논문에서 사용할 경우, “Nrgn-flox Mouse (카탈로그 번호 S-CKO-18181)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Nrgn-flox
품종 계통계통 ID
CKOCMP-64011-Nrgn-B6J-VB
유전자명
제품 ID
S-CKO-18181
유전자 별칭
NG, RC3, Pss1, NG/RC3, 0710001B06Rik
배경
C57BL/6JCya
NCBI ID
변형 내용
Conditional knockout
염색체
Chr 9
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000065668
NCBI 전사체 ID
NM_022029
타겟 영역
Exon 2~3
유효 영역 크기
~1.2 kb
유전자 연구 개요
Nrgn, or neurogranin, is a small brain protein expressed in various telencephalic areas. It plays an essential role in synaptic plasticity by regulating the availability of calmodulin (CaM) [4].
In glioma, NRGN acts as a tumor suppressor. LINC00641 can upregulate NRGN by absorbing miR-4262, thus inhibiting glioma cell proliferation [1]. Also, in glioblastoma, lncRNA RBPMS-AS1 promotes NRGN transcription through the miR-301a-3p/CAMTA1 axis, enhancing the radiosensitivity of glioblastoma [5].
In patients with mild traumatic brain injury, serum NRGN levels are significantly higher in those with traumatic intracranial lesions compared to those without, suggesting its potential as a diagnostic biomarker [2]. Moreover, a single-nucleotide polymorphism (rs12807809) in the NRGN gene is associated with abnormal Papez circuit function in schizophrenia patients [3]. Additionally, in the Han Chinese population, polymorphisms in NRGN are associated with schizophrenia, major depressive disorder, and bipolar disorder [8].
In Alzheimer's disease, NRGN levels in neuron-derived extracellular vesicles in plasma are elevated, potentially serving as a biomarker [7]. In adults with obstructive sleep apnea without dementia, higher levels of NRGN in neuron-derived exosomes are associated with cognitive impairment [6].
In conclusion, Nrgn is crucial for synaptic plasticity. Its study in various disease models has revealed its significance in glioma, traumatic brain injury, schizophrenia, mental disorders, Alzheimer's disease, and obstructive sleep apnea-related cognitive impairment. These findings contribute to understanding the disease mechanisms and may offer new diagnostic and therapeutic targets.
References：
1. Yang, Jinghui, Yu, Duo, Liu, Xueshibojie, Changyong, E, Yu, Shan. 2020. LINC00641/miR-4262/NRGN axis confines cell proliferation in glioma. In Cancer biology & therapy, 21, 758-766. doi:10.1080/15384047.2020.1776581. https://pubmed.ncbi.nlm.nih.gov/32543324/
2. Çevik, Serdar, Özgenç, Mustafa Murat, Güneyk, Ahmet, Hanımoğlu, Hakan, Kaynar, Mehmet Yaşar. 2019. NRGN, S100B and GFAP levels are significantly increased in patients with structural lesions resulting from mild traumatic brain injuries. In Clinical neurology and neurosurgery, 183, 105380. doi:10.1016/j.clineuro.2019.105380. https://pubmed.ncbi.nlm.nih.gov/31234132/
3. Zhang, Yifan, Gong, Xiaohong, Yin, Zhiyang, Wang, Fei, Tang, Yanqing. 2019. Association between NRGN gene polymorphism and resting-state hippocampal functional connectivity in schizophrenia. In BMC psychiatry, 19, 108. doi:10.1186/s12888-019-2088-5. https://pubmed.ncbi.nlm.nih.gov/30953482/
4. Rueda-García, Valentina, Rondón-Barragán, Iang Schroniltgen. 2023. Molecular Characterization of Neurogranin (NRGN) Gene from Red‑Bellied Pacu (Piaractus brachypomus). In Molecular neurobiology, 61, 2620-2630. doi:10.1007/s12035-023-03700-5. https://pubmed.ncbi.nlm.nih.gov/37922064/
5. Li, Wenyang, Cui, Yan, Ma, Wenjia, Cai, Yang, Jiang, Yugang. 2021. LncRNA RBPMS-AS1 promotes NRGN transcription to enhance the radiosensitivity of glioblastoma through the microRNA-301a-3p/CAMTA1 axis. In Translational oncology, 15, 101282. doi:10.1016/j.tranon.2021.101282. https://pubmed.ncbi.nlm.nih.gov/34800915/
6. Li, Mengfan, Shen, Tengqun, Yao, Ran, Li, Zhenguang, Zhang, Jinbiao. 2024. Mitochondrial dysfunction is associated with cognitive impairment in adults with OSA without dementia. In Sleep medicine, 119, 234-243. doi:10.1016/j.sleep.2024.04.035. https://pubmed.ncbi.nlm.nih.gov/38704871/
7. Eitan, Erez, Thornton-Wells, Tricia, Elgart, Katya, Smith, Daniel G, Kapogiannis, Dimitrios. 2023. Synaptic proteins in neuron-derived extracellular vesicles as biomarkers for Alzheimer's disease: novel methodology and clinical proof of concept. In Extracellular vesicles and circulating nucleic acids, 4, 133-150. doi:10.20517/evcna.2023.13. https://pubmed.ncbi.nlm.nih.gov/37842184/
8. Wen, Zujia, Chen, Jianhua, Khan, Raja Amjad Waheed, Li, Wenjin, Shi, Yongyong. 2016. Polymorphisms in NRGN are associated with schizophrenia, major depressive disorder and bipolar disorder in the Han Chinese population. In Journal of affective disorders, 194, 180-7. doi:10.1016/j.jad.2016.01.034. https://pubmed.ncbi.nlm.nih.gov/26828755/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
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