Glg1-flox Mouse
Common Name
Glg1-flox
제품 ID
S-CKO-18792
Backgroud
C57BL/6JCya
품종 계통계통 ID
CKOCMP-20340-Glg1-B6J-VB
상태
이 마우스 계통을 논문에서 사용할 경우, “Glg1-flox Mouse (카탈로그 번호 S-CKO-18792)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Glg1-flox
품종 계통계통 ID
CKOCMP-20340-Glg1-B6J-VB
유전자명
제품 ID
S-CKO-18792
유전자 별칭
CFR, CFR-1, ESL-1, MG160, Selel, MG-160
배경
C57BL/6JCya
NCBI ID
변형 내용
Conditional knockout
염색체
Chr 8
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000169020
NCBI 전사체 ID
NM_009149
타겟 영역
Exon 13~16
유효 영역 크기
~3.7 kb
유전자 연구 개요
GLG1, also known as Golgi glycoprotein 1, is an intracellular fibroblast growth factor receptor located in the Golgi apparatus [2]. It may function as a decoy FGF receptor [2]. GLG1 is associated with various biological processes and diseases. In cancer, it has been studied in relation to Ewing sarcoma, malignant glioma, breast cancer, and gastric cancer [1,2,3]. It is also involved in estrogen synthesis regulation in mouse ovarian granulosa cells [4], and a circular RNA derived from GLG1 mRNA (circ_GLG1) plays a role in colorectal cancer progression [5].
In Ewing sarcoma, high BCL11B and/or GLG1 immunoreactivity in CD99-positive cases shows high specificity (97.5%) and accuracy (87.4%) for diagnosis by immunohistochemistry, helping as specific auxiliary markers in diagnosing Ewing sarcoma especially when confirmatory molecular diagnostics are unavailable [1]. In malignant glioma and breast cancer cells, memantine treatment up-regulates GLG1 mRNA expression, changes its splicing variant profiles, and alters its cellular location, suggesting a role in the cancer-suppressive effects of memantine [2]. In gastric cancer, FUT3 promotes cell migration by synthesizing Lea on GLG1, affecting its distribution in intracellular vesicles [3]. In mouse ovarian granulosa cells, taurine down-regulates GLG1, and GLG1 knockdown increases estrogen synthesis, indicating its role in the p38/miR-7a/Glg1/Cyp19a1 signaling pathway for estrogen synthesis [4]. In colorectal cancer, circ_GLG1 promotes KRAS expression by acting as an miR-622 sponge, affecting cancer cell viability, proliferation, invasion, and migration [5].
In summary, GLG1 is involved in multiple biological processes and diseases. Its study in different cancer types and estrogen synthesis regulation provides insights into its functions. Research on GLG1, especially through the findings in these disease-related studies, helps understand the underlying molecular mechanisms, which may contribute to the development of new diagnostic and therapeutic strategies for related diseases.
References：
1. Orth, Martin F, Hölting, Tilman L B, Dallmayer, Marlene, Kirchner, Thomas, Grünewald, Thomas G P. 2020. High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma. In Cancers, 12, . doi:10.3390/cancers12030644. https://pubmed.ncbi.nlm.nih.gov/32164354/
2. Yamaguchi, Fumio, Hayakawa, Sumio, Kawashima, Shota, Asakura, Takayuki, Oishi, Yumiko. 2022. Antitumor effect of memantine is related to the formation of the splicing isoform of GLG1, a decoy FGF‑binding protein. In International journal of oncology, 61, . doi:10.3892/ijo.2022.5370. https://pubmed.ncbi.nlm.nih.gov/35543162/
3. Wu, Fei, Cao, Li, Zhang, Jinyuan, Qin, Yannan, Huang, Chen. 2024. FUT3 promotes gastric cancer cell migration by synthesizing Lea on ITGA6 and GLG1, affecting adhesion and vesicle distribution. In Life sciences, 359, 123193. doi:10.1016/j.lfs.2024.123193. https://pubmed.ncbi.nlm.nih.gov/39477144/
4. Li, Liuhui, Lu, Chenyang, Zhang, Di, Liu, Hui, Cui, Sheng. 2022. Taurine promotes estrogen synthesis by regulating microRNA-7a2 in mice ovarian granulosa cells. In Biochemical and biophysical research communications, 626, 129-134. doi:10.1016/j.bbrc.2022.07.084. https://pubmed.ncbi.nlm.nih.gov/35988296/
5. Hao, Shuhong, Qu, Rongfeng, Hu, Chunmei, Wang, Min, Li, Yarong. 2020. A Circular RNA Derived from Golgi Glycoprotein 1 mRNA Regulates KRAS Expression and Promotes Colorectal Cancer Progression by Targeting microRNA-622. In OncoTargets and therapy, 13, 12637-12648. doi:10.2147/OTT.S284032. https://pubmed.ncbi.nlm.nih.gov/33335404/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
Cyagen문의하기
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