Ifi207-flox Mouse

Ifi207 is a member of the PYHIN and Alr gene families. It is a young and fast-evolving gene that plays crucial roles in innate immunity, particularly in cytokine regulation and antiviral responses. It is involved in pathways such as the STING-mediated response, which is important for the body's defense against pathogens [2,3].

Generation of Ifi207-/-mice showed that IFI207 is not involved in autoimmunity. Instead, it is required for the establishment of Klebsiella pneumoniae lung infection and macrophage phagocytosis of Klebsiella [1]. In addition, in vivo studies demonstrated that IFI207 controls murine leukemia virus (MLV) infection by stabilizing STING protein through its distinctive repeat region in the STING-mediated response to cGAMP, DNA, and MLV [2,3].

In conclusion, Ifi207 is essential for innate immune responses, contributing to the regulation of cytokine transcription, pathogen-specific infections like K. pneumoniae, and antiviral defense against retroviruses such as MLV. The use of Ifi207 knockout mouse models has been instrumental in revealing its functions in these biological processes and disease-related contexts.