Ankrd60-flox Mouse

Ankrd60, also known as ankyrin repeat domain 60, has been associated with multiple biological aspects. In humans, it is linked to body height [3]. Its role in specific pathways is yet to be fully elucidated, but its association with height indicates its importance in growth-related biological processes. Genetic models can potentially be valuable in further exploring its functions.

In Nordic Red cattle, Ankrd60 was identified as a candidate gene for the female fertility index (FTI) located on BTA13. Although it's not clear how this gene regulates female fertility, the majority of genes in similar studies were involved in protein binding [1].

In Icelandic horses, ANKRD60, along with other genes, was found in a genomic region associated with the conformation of back and croup. This region also influenced the quality of lateral gaits. Additionally, ANKRD60 is potentially linked to adolescent idiopathic scoliosis in humans [2].

In conclusion, Ankrd60 appears to be involved in diverse biological functions across different species. In cattle, it may play a role in female fertility, while in horses, it could be associated with body conformation and gait quality. In humans, it has connections to body height and potentially adolescent idiopathic scoliosis. Studies on Ankrd60 using genetic models can help further clarify its functions and contributions to these biological processes and potential disease areas. [1,2,3]