Ms4a7-KO Mouse
Common Name
Ms4a7-KO
제품 ID
S-KO-00672
Backgroud
C57BL/6JCya
품종 계통계통 ID
KOCMP-109225-Ms4a7-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Ms4a7-KO Mouse (카탈로그 번호 S-KO-00672)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Ms4a7-KO
품종 계통계통 ID
KOCMP-109225-Ms4a7-B6J-VA
유전자명
제품 ID
S-KO-00672
유전자 별칭
CFFMA, CD20l4, 9130422I10Rik, A430103C15Rik
배경
C57BL/6JCya
NCBI ID
변형 내용
Conventional knockout
염색체
Chr 19
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000025574
NCBI 전사체 ID
NM_001276398
타겟 영역
Exon 2~5
유효 영역 크기
~10.3 kb
유전자 연구 개요
Ms4a7, encoding a membrane-spanning 4-domains protein, is involved in multiple biological processes. It has been implicated in immune-related pathways and is potentially important in various disease conditions, with gene knockout models being valuable for studying its functions [1,2,3,4,5,6,7,8,9,10].
In metabolic dysfunction-associated steatohepatitis (MASH), hepatic Ms4a7 expression is strongly induced in mouse and human cases. Whole-body and myeloid-specific ablation of Ms4a7 alleviated diet-induced MASH pathologies in male mice. It was found that lipid droplets released from injured steatotic hepatocytes triggered NAM induction and MASH-associated liver injury in an Ms4a7-dependent manner, and Ms4a7 drove NLRP3 inflammasome activation via direct physical interaction [1]. In glioblastoma, the short isoform of MS4A7 (MS4A7-s) promotes activation of glioma-associated macrophages' PI3K/AKT/GSK3β pathway, leading to M2 polarization and driving malignant progression of GBM [2].
In conclusion, Ms4a7 plays a role in the pathogenesis of diseases like MASH and glioblastoma. The use of Ms4a7 knockout mouse models has revealed its significance in these disease areas, mainly through its impact on immune-related processes and cell-signaling pathways, highlighting its potential as a therapeutic target in relevant diseases.
References:
1. Zhou, Linkang, Qiu, Xiaoxue, Meng, Ziyi, Li, Siming, Lin, Jiandie D. 2024. Hepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation. In Science translational medicine, 16, eadk1866. doi:10.1126/scitranslmed.adk1866. https://pubmed.ncbi.nlm.nih.gov/38478630/
2. Ni, Bowen, Huang, Guanglong, Yang, Runwei, Shen, Jie, Liu, Yawei. 2023. The short isoform of MS4A7 is a novel player in glioblastoma microenvironment, M2 macrophage polarization, and tumor progression. In Journal of neuroinflammation, 20, 80. doi:10.1186/s12974-023-02766-1. https://pubmed.ncbi.nlm.nih.gov/36944954/
3. Pang, Jianyu, Yu, Qian, Chen, Yongzhi, Sheng, Miaomiao, Tang, Wenru. 2022. Integrating Single-cell RNA-seq to construct a Neutrophil prognostic model for predicting immune responses in non-small cell lung cancer. In Journal of translational medicine, 20, 531. doi:10.1186/s12967-022-03723-x. https://pubmed.ncbi.nlm.nih.gov/36401283/
4. Zhou, Linkang, Lu, You, Qiu, Xiaoxue, Li, Siming, Lin, Jiandie D. 2025. Lipid droplet efferocytosis attenuates proinflammatory signaling in macrophages via TREM2- and MS4A7-dependent mechanisms. In Cell reports, 44, 115310. doi:10.1016/j.celrep.2025.115310. https://pubmed.ncbi.nlm.nih.gov/39954254/
5. Feng, Cheng, Shan, Mengjie, Xia, Yijun, Wang, Youbin, Huang, Yongsheng. 2022. Single-cell RNA sequencing reveals distinct immunology profiles in human keloid. In Frontiers in immunology, 13, 940645. doi:10.3389/fimmu.2022.940645. https://pubmed.ncbi.nlm.nih.gov/35990663/
6. Wu, Haoming, Feng, Jikun, Zhong, Wenjing, Wang, Xi, Yi, Jiarong. 2023. Model for predicting immunotherapy based on M2 macrophage infiltration in TNBC. In Frontiers in immunology, 14, 1151800. doi:10.3389/fimmu.2023.1151800. https://pubmed.ncbi.nlm.nih.gov/36999020/
7. Shamseldin, Hanan E, Kurdi, Wesam, Almusafri, Fatima, Faqeih, Eissa, Alkuraya, Fowzan S. 2017. Molecular autopsy in maternal-fetal medicine. In Genetics in medicine : official journal of the American College of Medical Genetics, 20, 420-427. doi:10.1038/gim.2017.111. https://pubmed.ncbi.nlm.nih.gov/28749478/
8. Sun, Lei, Zhang, Yanli, Zhang, Chao. 2018. Distinct Expression and Prognostic Value of MS4A in Gastric Cancer. In Open medicine (Warsaw, Poland), 13, 178-188. doi:10.1515/med-2018-0028. https://pubmed.ncbi.nlm.nih.gov/29756054/
9. Houlahan, Kathleen E, Prokopec, Stephenie D, Sun, Ren X, Pohjanvirta, Raimo, Boutros, Paul C. 2015. Transcriptional profiling of rat white adipose tissue response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin. In Toxicology and applied pharmacology, 288, 223-31. doi:10.1016/j.taap.2015.07.018. https://pubmed.ncbi.nlm.nih.gov/26232522/
10. Yang, S M, Wu, S B, Wu, J M, Sun, W P, Xiao, L Z. . [The molecular mechanism of oxaliplatin-induced peripheral neuropathic pain]. In Zhonghua yi xue za zhi, 101, 3581-3587. doi:10.3760/cma.j.cn112137-20210513-01127. https://pubmed.ncbi.nlm.nih.gov/34808752/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
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