Ggct-KO Mouse
Common Name
Ggct-KO
제품 ID
S-KO-00741
Backgroud
C57BL/6JCya
품종 계통계통 ID
KOCMP-110175-Ggct-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Ggct-KO Mouse (카탈로그 번호 S-KO-00741)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Ggct-KO
품종 계통계통 ID
KOCMP-110175-Ggct-B6J-VA
유전자명
제품 ID
S-KO-00741
유전자 별칭
Ggc, Gctg, A030007L17Rik
배경
C57BL/6JCya
NCBI ID
변형 내용
Conventional knockout
염색체
Chr 6
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000131475
NCBI 전사체 ID
NM_026637
타겟 영역
Exon 1~4
유효 영역 크기
~10.4 kb
유전자 연구 개요
Ggct, also known as γ -glutamylcyclotransferase, is an important enzyme in the glutathione metabolism pathway. Glutathione is crucial for maintaining cellular redox balance, and thus Ggct plays a significant role in various biological processes related to antioxidant defense [3,4,7].
In p53 -deficient osteosarcoma, Myc upregulates Ggct by binding to its promoter, and deletion of Ggct suppresses osteosarcomagenesis in mice, suggesting Ggct's role in promoting tumor development [2]. In mice, Ggct deletion leads to splenomegaly and progressive anaemia due to elevated oxidative damage and shortened lifespan of red blood cells, highlighting its importance in erythrocyte antioxidant defense and survival [3]. In multiple cancer types such as colorectal cancer, glioma, papillary thyroid cancer, and bladder urothelial cell carcinoma, high Ggct expression is associated with poor prognosis, and its knockdown inhibits cancer cell proliferation, migration, invasion, and in some cases, promotes ferroptosis [1,5,6,8,9,10].
In conclusion, Ggct is essential for maintaining cellular redox balance, especially in erythrocytes. Through gene knockout mouse models, it has been revealed that Ggct plays a role in promoting the development of certain cancers. These findings highlight Ggct as a potential therapeutic target in cancer treatment [2,3,1,5,6,8,9,10].
References:
1. Huang, Qi, Zhou, Yuanhang, Li, Yue, Liao, Zhiwei. 2020. GGCT promotes colorectal cancer migration and invasion via epithelial-mesenchymal transition. In Oncology letters, 20, 1063-1070. doi:10.3892/ol.2020.11692. https://pubmed.ncbi.nlm.nih.gov/32724344/
2. Ueno, Tomoya, Otani, Shohei, Date, Yuki, Nakata, Susumu, Ito, Kosei. 2024. Myc upregulates Ggct, γ-glutamylcyclotransferase to promote development of p53-deficient osteosarcoma. In Cancer science, 115, 2961-2971. doi:10.1111/cas.16255. https://pubmed.ncbi.nlm.nih.gov/38924236/
3. He, Zaoke, Sun, Xiaoqin, Wang, Shixiang, Hao, Piliang, Liu, Xue-Song. 2021. Ggct (γ-glutamyl cyclotransferase) plays an important role in erythrocyte antioxidant defense and red blood cell survival. In British journal of haematology, 195, 267-275. doi:10.1111/bjh.17775. https://pubmed.ncbi.nlm.nih.gov/34409610/
4. He, Zaoke, Wang, Shixiang, Shao, Yuanyuan, Zhang, Feng, Liu, Xue-Song. 2019. Ras Downstream Effector GGCT Alleviates Oncogenic Stress. In iScience, 19, 256-266. doi:10.1016/j.isci.2019.07.036. https://pubmed.ncbi.nlm.nih.gov/31400748/
5. Shen, Shang-Hang, Chen, Si-Fang, Guo, Jian-Feng, Wang, Zhan-Xiang. 2024. The GGCT and REST positive feedback loop promotes tumor growth in Glioma. In Translational oncology, 49, 102083. doi:10.1016/j.tranon.2024.102083. https://pubmed.ncbi.nlm.nih.gov/39128259/
6. Li, Han-Ning, Zhang, Hui-Min, Li, Xing-Rui, Liao, Xing-Hua, Du, Ya-Ying. . MiR-205-5p/GGCT Attenuates Growth and Metastasis of Papillary Thyroid Cancer by Regulating CD44. In Endocrinology, 163, . doi:10.1210/endocr/bqac022. https://pubmed.ncbi.nlm.nih.gov/35213720/
7. Kageyama, Susumu, Ii, Hiromi, Taniguchi, Keiko, Kawauchi, Akihiro, Nakata, Susumu. 2018. Mechanisms of Tumor Growth Inhibition by Depletion of γ-Glutamylcyclotransferase (GGCT): A Novel Molecular Target for Anticancer Therapy. In International journal of molecular sciences, 19, . doi:10.3390/ijms19072054. https://pubmed.ncbi.nlm.nih.gov/30011933/
8. Zhang, Hui-Min, Li, Han-Ning, Qi, Enbo, Yang, Zhi-Fang, Liao, Xing-Hua. 2025. GGCT Inhibits Ferroptosis in PTC Cells by Upregulating p53 Through RPS15A. In Cancer science, , . doi:10.1111/cas.70039. https://pubmed.ncbi.nlm.nih.gov/40044122/
9. Zhang, Hui-Min, Li, Zi-Yi, Dai, Zhou-Tong, Zhang, Tong-Cun, Liao, Xing-Hua. 2022. Interaction of MRPL9 and GGCT Promotes Cell Proliferation and Migration by Activating the MAPK/ERK Pathway in Papillary Thyroid Cancer. In International journal of molecular sciences, 23, . doi:10.3390/ijms231911989. https://pubmed.ncbi.nlm.nih.gov/36233293/
10. Guo, Y S, Wu, Y D, Ma, H, Zhang, S D, Zang, Y J. . [The expression of GGCT in the bladder urothelial cell carcinoma and its clinical significance]. In Zhonghua zhong liu za zhi [Chinese journal of oncology], 43, 1183-1187. doi:10.3760/cma.j.cn112152-20200326-00264. https://pubmed.ncbi.nlm.nih.gov/34794221/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
Cyagen문의하기
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