Gstm1-KO Mouse
Common Name
Gstm1-KO
제품 ID
S-KO-02355
Backgroud
C57BL/6JCya
품종 계통계통 ID
KOCMP-14862-Gstm1-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Gstm1-KO Mouse (카탈로그 번호 S-KO-02355)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Gstm1-KO
품종 계통계통 ID
KOCMP-14862-Gstm1-B6J-VA
유전자명
제품 ID
S-KO-02355
유전자 별칭
Gstb1, Gstb-1
배경
C57BL/6JCya
NCBI ID
변형 내용
Conventional knockout
염색체
Chr 3
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000126593
NCBI 전사체 ID
NM_001374678.1
타겟 영역
Exon 3~5
유효 영역 크기
~1.1 kb
유전자 연구 개요
Gstm1, glutathione S-transferase M1, is a gene encoding an enzyme responsible for the detoxification of substances harmful to the human body, such as air pollution, drugs, pesticides, and tobacco [1]. As part of the glutathione S-transferase family, it protects cells from oxidative stress and may also be involved in negatively regulating apoptosis-related signalling cascades through protein-protein interactions [3].
Regarding its association with diseases, some studies suggest that Gstm1 null genotype may not be associated with pre-eclampsia risk [2], renal cell carcinoma [4], basal and squamous cell carcinomas [5], or hypertension [6]. However, in Chinese populations, the Gstm1 null genotype is associated with an increased risk of lung cancer [7]. In Asians, the Gstm1 null genotype may be associated with a higher risk of oral cancer, and this effect may be modified by smoking status [8]. In Chinese and Indian populations, the Gstm1 null genotype is associated with the development of cervical cancer, and smoking modifies this association [9].
In conclusion, Gstm1 plays a crucial role in detoxification and potentially in apoptosis regulation. Studies on its null genotype across various ethnic groups have revealed associations with different diseases, such as lung, oral, and cervical cancers. Understanding Gstm1's function through genetic models like gene knockout could further clarify its role in disease mechanisms, offering potential insights for disease prevention and treatment.
References:
1. Nakanishi, Giovana, Bertagnolli, Laísa S, Pita-Oliveira, Murilo, Cirino, Heithor S, Rodrigues-Soares, Fernanda. 2022. GSTM1 and GSTT1 polymorphisms in healthy volunteers - a worldwide systematic review. In Drug metabolism reviews, 54, 37-45. doi:10.1080/03602532.2022.2036996. https://pubmed.ncbi.nlm.nih.gov/35103568/
2. Li, Lin, Wang, Ao, Ke, Yi. . GSTM1 and GSTT1 polymorphisms and risk of preeclampsia: a system review and meta-analysis. In The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 36, 2237623. doi:10.1080/14767058.2023.2237623. https://pubmed.ncbi.nlm.nih.gov/37469043/
3. Zhao, Jian, Wang, Lixian, Li, Yan, Zhao, Wei, Kang, Shan. . Hypomethylation of the GSTM1 promoter is associated with ovarian endometriosis. In Human reproduction (Oxford, England), 34, 804-812. doi:10.1093/humrep/dez039. https://pubmed.ncbi.nlm.nih.gov/30989213/
4. Liu, Rui, Wang, Xiao-Hua, Liu, Li, Zhou, Qiang. . No association between the GSTM1 null genotype and risk of renal cell carcinoma: a meta-analysis. In Asian Pacific journal of cancer prevention : APJCP, 13, 3109-12. doi:. https://pubmed.ncbi.nlm.nih.gov/22994718/
5. Peng, Hao, He, Quanyong, Zhu, Jie, Peng, Cheng. 2012. Effect of GSTM1 polymorphism on risks of basal cell carcinoma and squamous cell carcinoma: a meta-analysis. In Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 34, 675-81. doi:10.1007/s13277-012-0595-9. https://pubmed.ncbi.nlm.nih.gov/23184764/
6. Ge, Beihai, Song, Yadong, Zhang, Yi, Wen, Yuxiang, Guo, Xiaomei. 2015. Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) null polymorphisms and the risk of hypertension: a meta-analysis. In PloS one, 10, e0118897. doi:10.1371/journal.pone.0118897. https://pubmed.ncbi.nlm.nih.gov/25742618/
7. Shi, Xiuquan, Zhou, Suhua, Wang, Zhongxu, Zhou, Zongcan, Wang, Zengzhen. 2007. CYP1A1 and GSTM1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis. In Lung cancer (Amsterdam, Netherlands), 59, 155-63. doi:. https://pubmed.ncbi.nlm.nih.gov/17900751/
8. Zhang, Zhi-Jiang, Hao, Ke, Shi, Rong, Xu, Xiaohui, Ma, Jin. 2011. Glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms, smoking, and their interaction in oral cancer: a HuGE review and meta-analysis. In American journal of epidemiology, 173, 847-57. doi:10.1093/aje/kwq480. https://pubmed.ncbi.nlm.nih.gov/21436184/
9. Liu, Ying, Xu, Liang-Zhi. . Meta-analysis of association between GSTM1 gene polymorphism and cervical cancer. In Asian Pacific journal of tropical medicine, 5, 480-4. doi:10.1016/S1995-7645(12)60083-2. https://pubmed.ncbi.nlm.nih.gov/22575983/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
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