Kif11-KO Mouse
Common Name
Kif11-KO
제품 ID
S-KO-02779
Backgroud
C57BL/6JCya
품종 계통계통 ID
KOCMP-16551-Kif11-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Kif11-KO Mouse (카탈로그 번호 S-KO-02779)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Kif11-KO
품종 계통계통 ID
KOCMP-16551-Kif11-B6J-VA
유전자명
제품 ID
S-KO-02779
유전자 별칭
Eg5, Kif8, Kifl1, Knsl1
배경
C57BL/6JCya
NCBI ID
변형 내용
Conventional knockout
염색체
Chr 19
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000012587
NCBI 전사체 ID
NM_010615
타겟 영역
Exon 2~4
유효 영역 크기
~2.7 kb
유전자 연구 개요
KIF11, a member of the kinesin family, plays a vital role in the formation and maintenance of the mitotic spindle, thus being crucial for cell division. It is also involved in various cellular processes, such as those related to the cell cycle [3].
KIF11 depletion in photoreceptor cells causes malformations of the ciliary axoneme and membranous discs, leading to photoreceptor degeneration and drusen-like deposits in the retina. This indicates its importance in maintaining photoreceptor cilium integrity and retinal homeostasis [1]. In hepatocellular carcinoma, KIF11-dependent repression of CDKN2A by lncRNA NEAT1 is associated with reduced cellular senescence and promoted tumor progression. Knockdown of KIF11 causes senescence in cultured hepatoma cells [2]. In multiple cancers like endometrial, thyroid, NSCLC, pancreatic ductal adenocarcinoma, adrenocortical carcinoma, childhood acute lymphoblastic leukemia, and Wilms tumor, high KIF11 expression is linked to tumorigenesis, progression, and poor prognosis. Loss-of-function experiments, such as knockdown of KIF11, inhibit cancer cell proliferation, migration, invasion, and induce apoptosis or cell cycle arrest [4,5,6,7,8,9,10].
In conclusion, KIF11 is essential for mitosis and the cell cycle. Model-based research, especially loss-of-function experiments, has revealed its significant roles in retinal homeostasis and cancer development. These findings suggest KIF11 could be a potential therapeutic target for diseases like cancer and retinal disorders.
References:
1. Ran, Jie, Guo, Guizhi, Zhang, Sai, Zhou, Jun, Liu, Min. 2024. KIF11 UFMylation Maintains Photoreceptor Cilium Integrity and Retinal Homeostasis. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11, e2400569. doi:10.1002/advs.202400569. https://pubmed.ncbi.nlm.nih.gov/38666385/
2. Chen, Danlei, Wang, Jinghao, Li, Yang, Zhang, Pengfei, Liu, Lianxin. . LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11-dependent repression of CDKN2A. In Clinical and translational medicine, 13, e1418. doi:10.1002/ctm2.1418. https://pubmed.ncbi.nlm.nih.gov/37752791/
3. Gao, Wanting, Lu, Junjie, Yang, Zitao, Cao, Yufei, Xie, Lei. 2024. Mitotic Functions and Characters of KIF11 in Cancers. In Biomolecules, 14, . doi:10.3390/biom14040386. https://pubmed.ncbi.nlm.nih.gov/38672404/
4. Wang, Biying, Bao, Lunmin, Li, Xiaoduo, Yuan, Rui, Jiang, Hongmei. 2025. Identification and validation of the important role of KIF11 in the development and progression of endometrial cancer. In Journal of translational medicine, 23, 48. doi:10.1186/s12967-025-06081-6. https://pubmed.ncbi.nlm.nih.gov/39806429/
5. Han, Yue, Chen, Jing, Wei, Dianjun, Wang, Baoxi. 2022. KIF11 Is a Promising Therapeutic Target for Thyroid Cancer Treatment. In Computational and mathematical methods in medicine, 2022, 6426800. doi:10.1155/2022/6426800. https://pubmed.ncbi.nlm.nih.gov/36017147/
6. Liu, Junhui, Tian, Yubin, Yi, Lei, Lou, Ming, Yuan, Kai. 2021. High KIF11 expression is associated with poor outcome of NSCLC. In Tumori, 108, 40-46. doi:10.1177/0300891620988342. https://pubmed.ncbi.nlm.nih.gov/33554761/
7. Gu, Xiang, Zhu, Qunshan, Tian, Guangyu, Chen, Xiaojun, Qin, Songbing. 2022. KIF11 manipulates SREBP2-dependent mevalonate cross talk to promote tumor progression in pancreatic ductal adenocarcinoma. In Cancer medicine, 11, 3282-3295. doi:10.1002/cam4.4683. https://pubmed.ncbi.nlm.nih.gov/35619540/
8. Zhou, Yan, Chen, Xiang, Li, Bingsheng, Li, Yang, Zhang, Bo. 2023. KIF11 is a potential prognostic biomarker and therapeutic target for adrenocortical carcinoma. In Translational andrology and urology, 12, 594-611. doi:10.21037/tau-22-706. https://pubmed.ncbi.nlm.nih.gov/37181234/
9. Zhu, Liwen, Chen, Chuqin, Kang, Meiyun, Xue, Yao, Fang, Yongjun. 2023. KIF11 serves as a cell cycle mediator in childhood acute lymphoblastic leukemia. In Journal of cancer research and clinical oncology, 149, 15609-15622. doi:10.1007/s00432-023-05240-w. https://pubmed.ncbi.nlm.nih.gov/37656243/
10. Luo, Yishu, Liu, Wei, Zhu, Yinmei, Liu, Xiaoqin, Zhao, Jun. 2021. KIF11 as a potential cancer prognostic marker promotes tumorigenesis in children with Wilms tumor. In Pediatric hematology and oncology, 39, 145-157. doi:10.1080/08880018.2021.1953655. https://pubmed.ncbi.nlm.nih.gov/34378481/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
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