Lepr-KO Mouse
Common Name
Lepr-KO
제품 ID
S-KO-02879
Backgroud
C57BL/6JCya
품종 계통계통 ID
KOCMP-16847-Lepr-B6J-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Lepr-KO Mouse (카탈로그 번호 S-KO-02879)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Lepr-KO
품종 계통계통 ID
KOCMP-16847-Lepr-B6J-VA
유전자명
제품 ID
S-KO-02879
유전자 별칭
db, Obr, obl, Leprb, Modb1, LEPROT, OB-RGRP, diabetes, obese-like
배경
C57BL/6JCya
NCBI ID
변형 내용
Conventional knockout
염색체
Chr 4
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000106921
NCBI 전사체 ID
NM_001122899
타겟 영역
Exon 3~4
유효 영역 크기
~2.4 kb
유전자 연구 개요
Lepr, short for leptin receptor, is a crucial protein that binds to leptin, a hormone regulating food intake and energy expenditure. This interaction is involved in pathways related to metabolism, energy homeostasis, and potentially in disease-associated processes like those related to obesity, diabetes, and cancer. Genetic models, such as gene knockout (KO) or conditional knockout (CKO) mouse models, are valuable in studying Lepr's functions [1,2,3].
Meta-analysis of 16 studies with 7827 subjects suggested that the LEPR Gln223Arg polymorphism may not affect the susceptibility to type 2 diabetes (T2DM) [1]. Another meta-analysis including 5819 cases and 8068 controls found that the LEPR K109R (rs1137100) genetic polymorphism did not significantly affect the overall cancer risk, but was associated with decreased breast cancer susceptibility under the additive genetic model and had associations with lung and gastric cancer in some genetic models [3]. In Mexican patients, the c.326A>G heterozygous genotype of LEPR was linked to an increased risk of colorectal cancer, while the AG haplotype had a protective effect [4]. A study on Chinese Mulao people showed that certain LEPR SNPs were associated with osteoporosis [5]. Also, in the Ukrainian population, the LEPR (rs1137101) polymorphism indicated an increased risk of the metabolic syndrome [6]. One meta-analysis including 5143 T2DM cases and 5021 controls found that rs1137101 (p.R223Q) in LEPR was significantly associated with T2DM in all genetic models [7].
In conclusion, Lepr is essential for maintaining energy homeostasis and metabolism through its interaction with leptin. Studies using genetic models have revealed its associations with multiple diseases including T2DM, various cancers, osteoporosis, and the metabolic syndrome. Understanding Lepr's functions through these models provides insights into the disease mechanisms and may offer potential targets for disease prevention and treatment.
References:
1. Liu, Ying, Chen, Shu-Qin, Jing, Zhao-Hai, Wang, Robin, Wang, Yan-Gang. 2015. Association of LEPR Gln223Arg polymorphism with T2DM: A meta-analysis. In Diabetes research and clinical practice, 109, e21-6. doi:10.1016/j.diabres.2015.05.042. https://pubmed.ncbi.nlm.nih.gov/26094585/
2. Delplanque, Jérôme, Le Collen, Lauriane, Loiselle, Hélène, Froguel, Philippe, Bonnefond, Amélie. 2024. Monoallelic pathogenic variants in LEPR do not cause obesity. In American journal of human genetics, 111, 2668-2674. doi:10.1016/j.ajhg.2024.10.014. https://pubmed.ncbi.nlm.nih.gov/39561769/
3. Shi, Hui, Shu, Hexi, Huang, Changjia, Yang, Yong, Liu, Pengcheng. . Association of LEPR K109R polymorphisms with cancer risk: a systematic review and pooled analysis. In Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 19, 847-54. doi:. https://pubmed.ncbi.nlm.nih.gov/25261678/
4. Partida, Miriam, Gutiérrez, Melva, Ayala, María de la Luz, Alvizo, Carlos Rogelio, Peregrina, Jorge. 2019. LEPR polymorphisms and haplotypes in Mexican patients with colorectal cancer. In Biomedica : revista del Instituto Nacional de Salud, 39, 205-211. doi:10.7705/biomedica.v39i1.4091. https://pubmed.ncbi.nlm.nih.gov/31021558/
5. Ye, Guangbin, Huang, Yandong, Yin, Lianfei, Huang, Xiufeng, Bin, Xiaoyun. . Association between LEPR polymorphism and susceptibility of osteoporosis in Chinese Mulao people. In Artificial cells, nanomedicine, and biotechnology, 50, 10-16. doi:10.1080/21691401.2021.2020279. https://pubmed.ncbi.nlm.nih.gov/35086395/
6. Prodan, Andrii, Dzubanovsky, Ihor, Kamyshnyi, Oleksandr, Pidruchna, Svitlana, Voloshyn, Stanislava. 2023. GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population. In Endocrine regulations, 57, 269-278. doi:10.2478/enr-2023-0030. https://pubmed.ncbi.nlm.nih.gov/38127688/
7. Yang, Ming Ming, Wang, Jun, Fan, Jiao Jie, Teng, Yan, Li, Yan-Bo. 2016. Variations in the Obesity Gene "LEPR" Contribute to Risk of Type 2 Diabetes Mellitus: Evidence from a Meta-Analysis. In Journal of diabetes research, 2016, 5412084. doi:10.1155/2016/5412084. https://pubmed.ncbi.nlm.nih.gov/27195302/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
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