Pon1-KO Mouse
Common Name
Pon1-KO
제품 ID
S-KO-03736
Backgroud
C57BL/6NCya
품종 계통계통 ID
KOCMP-18979-Pon1-B6N-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Pon1-KO Mouse (카탈로그 번호 S-KO-03736)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Pon1-KO
품종 계통계통 ID
KOCMP-18979-Pon1-B6N-VA
유전자명
제품 ID
S-KO-03736
유전자 별칭
Pon
배경
C57BL/6NCya
NCBI ID
변형 내용
Conventional knockout
염색체
Chr 6
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000002663
NCBI 전사체 ID
NM_011134
타겟 영역
Exon 3~7
유효 영역 크기
~9.6 kb
유전자 연구 개요
PON1, also known as paraoxonase 1, is a high-density lipoprotein (HDL) associated enzyme. It has antioxidant, anti-inflammatory, and anti-apoptotic roles, and its most important enzymatic activity in association with HDL is preventing low-density lipoprotein (LDL) oxidation, thus having anti-atherogenic activity [2,6,7]. PON1 is also involved in the detoxification of organophosphate insecticides [3,8].
PON1 gene polymorphisms have been associated with various diseases. A meta-analysis showed that the PON1 L55M polymorphism might increase the risk of cancer, especially breast cancer in some stratified analyses, and also increase cancer risk in Caucasian populations and in hospital-based studies [1]. Some SNPs of the PON1 gene are associated with stroke [2]. The PON1 192Q and 55L polymorphisms may increase the risk of organophosphate toxicity, especially among Caucasian populations [3]. The polymorphism of PON1 is associated with an increased risk of liver disease, and liver disease significantly reduces PON1 activity [4]. In idiopathic inflammatory myopathies (IIM), the arylesterase and lactonase activities of PON1 are significantly lower, and the PON1 QQ genotype associates with more favorable disease outcomes [5]. A meta-analysis in Chinese population suggested a weak association between the PON1 Q192R polymorphism and coronary heart disease risk [9].
In conclusion, PON1 is crucial for maintaining HDL functionality and protecting against oxidative stress and organophosphate toxicity. Its gene polymorphisms are associated with an increased risk of various diseases such as cancer, stroke, liver disease, and organophosphate toxicity, as well as influencing disease outcomes in IIM and coronary heart disease in specific populations. The study of PON1 gene polymorphisms helps to understand disease susceptibility and progression, providing potential targets for disease prevention and treatment.
References:
1. Hu, Peizeng, Ma, Yongchen, Zhang, Lingling, Ma, Sheng. 2016. PON1 L55M polymorphism might contribute to the risk of cancer. In Panminerva medica, 59, 107-113. doi:10.23736/S0031-0808.16.03212-2. https://pubmed.ncbi.nlm.nih.gov/27309259/
2. Tajbakhsh, Amir, Rezaee, Mehdi, Rivandi, Mahdi, Afzaljavan, Fahimeh, Pasdar, Alireza. 2017. Paraoxonase 1 (PON1) and stroke; the dilemma of genetic variation. In Clinical biochemistry, 50, 1298-1305. doi:10.1016/j.clinbiochem.2017.08.001. https://pubmed.ncbi.nlm.nih.gov/28779954/
3. You, Tian, Lv, Jingyu, Zhou, Liping. 2013. PON1 Q192R and L55M polymorphisms and organophosphate toxicity risk: a meta-analysis. In DNA and cell biology, 32, 252-9. doi:10.1089/dna.2012.1961. https://pubmed.ncbi.nlm.nih.gov/23590198/
4. Salari, Nader, Kazeminia, Mohsen, Mansouri, Kamran, Hosseinian-Far, Amin, Mohammadi, Masoud. 2021. The Activity and Polymorphism of the PON1 in Patients with Chronic Liver Disease: a Systematic Review and Meta-analysis. In Journal of gastrointestinal cancer, 53, 745-755. doi:10.1007/s12029-021-00699-7. https://pubmed.ncbi.nlm.nih.gov/34467517/
5. Bae, Sangmee Sharon, Shahbazian, Ani, Wang, Jennifer, Reddy, Srinivasa T, Charles-Schoeman, Christina. . Abnormal paraoxonase-1 (PON1) enzyme activity in idiopathic inflammatory myopathies. In Rheumatology (Oxford, England), 61, 2512-2523. doi:10.1093/rheumatology/keab795. https://pubmed.ncbi.nlm.nih.gov/34698804/
6. Mahrooz, Abdolkarim. 2024. Pleiotropic functions and clinical importance of circulating HDL-PON1 complex. In Advances in clinical chemistry, 121, 132-171. doi:10.1016/bs.acc.2024.04.003. https://pubmed.ncbi.nlm.nih.gov/38797541/
7. Marsillach, Judit, Richter, Rebecca J, Costa, Lucio G, Furlong, Clement E. . Paraoxonase-1 (PON1) Status Analysis Using Non-Organophosphate Substrates. In Current protocols, 1, e25. doi:10.1002/cpz1.25. https://pubmed.ncbi.nlm.nih.gov/33484495/
8. Costa, Lucio G, Giordano, Gennaro, Cole, Toby B, Marsillach, Judit, Furlong, Clement E. 2012. Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity. In Toxicology, 307, 115-22. doi:10.1016/j.tox.2012.07.011. https://pubmed.ncbi.nlm.nih.gov/22884923/
9. Zhang, Zhen, Ou, Junke, Cai, Peiling, Niu, Bei, Li, Jian. . Association between the PON1 Q192R polymorphism and coronary heart disease in Chinese: A meta-analysis. In Medicine, 97, e11151. doi:10.1097/MD.0000000000011151. https://pubmed.ncbi.nlm.nih.gov/29952962/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
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