Stc1-KO Mouse
Common Name
Stc1-KO
제품 ID
S-KO-04572
Backgroud
C57BL/6NCya
품종 계통계통 ID
KOCMP-20855-Stc1-B6N-VA
상태
이 마우스 계통을 논문에서 사용할 경우, “Stc1-KO Mouse (카탈로그 번호 S-KO-04572)은 Cyagen에서 구입하였습니다.”라고 명시해 주시기 바랍니다.
구매 가능한 제품 종류
연령
Genotype
성별
수량
표준 제공 조건은 최소 3마리의 이형접합(heterozygous) 보균자를 보장합니다. 동형접합(homozygous) 보균자 및/또는 특정 성별에 대한 브리딩 서비스도 제공됩니다.
기본 정보
품종 계통
Stc1-KO
품종 계통계통 ID
KOCMP-20855-Stc1-B6N-VA
유전자명
제품 ID
S-KO-04572
유전자 별칭
Stc
배경
C57BL/6NCya
NCBI ID
변형 내용
Conventional knockout
염색체
Chr 14
Phenotype
Datasheet
적용 분야
--
품종 계통 설명
Ensembl 전사체 ID
ENSMUST00000014957
NCBI 전사체 ID
NM_009285
타겟 영역
Exon 2~3
유효 영역 크기
~0.9 kb
유전자 연구 개요
Stc1, or Stanniocalcin-1, is a gene with diverse functions. It is involved in multiple biological processes, such as cell proliferation, migration, and invasion. In cancer, it is associated with signaling pathways like TGF-β/SMAD4, YAP/CCL2/VEGFA/AKT, and Notch1, influencing tumor progression, metastasis, and stemness [1,3,5]. In asthma, it may act as an epithelium-derived relaxing factor (EpDRF) by modulating calcium channels [4].
In cancer research, various in vitro and in vivo experiments have been conducted. For example, in glioblastoma, silencing Stc1 inhibited cell proliferation and invasion through the TGF-β/SMAD4 pathway [3]. In melanoma, STC1 enhanced metastasis by promoting M2 macrophage recruitment and polarization, and silencing STC1 enhanced the efficacy of PD-1 immunotherapy [1]. In colorectal cancer, A20 upregulated STC1 to block the "eat-me" signal, promoting immune evasion [2]. In hepatocellular carcinoma, CAF-derived STC1 promoted tumor stemness via the Notch1 signaling pathway [5]. In ovarian cancer, STC1 promoted metastasis, lipid metabolism, and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis [6]. In bladder cancer, high STC1 expression predicted poor prognosis and was related to immune characteristics [7]. In colitis, STC1-deficient mice (Stc1INT-KO) were resistant to DSS-induced colitis, as STC1 mediates oxidative stress-associated parthanatos and aggravates inflammation via the STC1-PARP1-JNK interactions [8].
In conclusion, Stc1 is a multifunctional gene involved in cancer progression, metastasis, immune evasion, and stemness, as well as in asthma airway hyperresponsiveness and colitis. Gene-knockout models, especially Stc1INT-KO mice in colitis, have been crucial in revealing its role in these disease conditions, providing insights into potential therapeutic targets.
References:
1. Ren, Zhaozhou, Xu, Zhijie, Chang, Xiyue, Liu, Jie, Xiao, Wan'an. 2024. STC1 competitively binding βPIX enhances melanoma progression via YAP nuclear translocation and M2 macrophage recruitment through the YAP/CCL2/VEGFA/AKT feedback loop. In Pharmacological research, 204, 107218. doi:10.1016/j.phrs.2024.107218. https://pubmed.ncbi.nlm.nih.gov/38768671/
2. Luo, Min, Wang, Xueping, Wu, Shaocong, Wang, Fang, Fu, Liwu. 2023. A20 promotes colorectal cancer immune evasion by upregulating STC1 expression to block "eat-me" signal. In Signal transduction and targeted therapy, 8, 312. doi:10.1038/s41392-023-01545-x. https://pubmed.ncbi.nlm.nih.gov/37607946/
3. Xiong, Yan, Wang, Qibai. 2019. STC1 regulates glioblastoma migration and invasion via the TGF‑β/SMAD4 signaling pathway. In Molecular medicine reports, 20, 3055-3064. doi:10.3892/mmr.2019.10579. https://pubmed.ncbi.nlm.nih.gov/31432189/
4. Xu, Jiayan, Meng, Yaqi, Jia, Man, Adcock, Ian M, Yao, Xin. 2021. Epithelial expression and role of secreted STC1 on asthma airway hyperresponsiveness through calcium channel modulation. In Allergy, 76, 2475-2487. doi:10.1111/all.14727. https://pubmed.ncbi.nlm.nih.gov/33378582/
5. Bai, Shuya, Zhao, Yuchong, Chen, Wei, Cheng, Bin, Wang, Ronghua. 2023. The stromal-tumor amplifying STC1-Notch1 feedforward signal promotes the stemness of hepatocellular carcinoma. In Journal of translational medicine, 21, 236. doi:10.1186/s12967-023-04085-8. https://pubmed.ncbi.nlm.nih.gov/37004088/
6. Lin, Feikai, Li, Xiaoduan, Wang, Xinjing, Wang, Ziliang, Wang, Xipeng. 2022. Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer. In Journal of experimental & clinical cancer research : CR, 41, 129. doi:10.1186/s13046-022-02315-3. https://pubmed.ncbi.nlm.nih.gov/35392966/
7. Sun, Jiale, Wei, Xuedong, You, Jiawei, Ling, Zhixin, Hou, Jianquan. 2021. STC1 is a Novel Biomarker Associated with Immune Characteristics and Prognosis of Bladder Cancer. In International journal of general medicine, 14, 5505-5516. doi:10.2147/IJGM.S329723. https://pubmed.ncbi.nlm.nih.gov/34539184/
8. Zhu, Liguo, Xie, Zhuo, Yang, Guang, Li, Li, Zhang, Shenghong. 2023. Stanniocalcin-1 Promotes PARP1-Dependent Cell Death via JNK Activation in Colitis. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11, e2304123. doi:10.1002/advs.202304123. https://pubmed.ncbi.nlm.nih.gov/38088577/
품질 관리 기준
정자 검사
동결 보존 전: 정자 농도 측정 및 정자 생존율 평가.
동결 보존 후: 각 배치에서 동결 보존된 정자 바이알 1개를 선택하여 체외수정(in vitro fertilization)에 사용합니다.
Environmental Standards:
SPFAvailable Region:
GlobalSource:
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